2-Methyl-6-quinolinecarboxylic Acid: Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
2-Methyl-6-quinolinecarboxylic acid (CAS 117-57-7) is a high-purity quinoline derivative widely used in pharmaceutical synthesis and organic catalysis. Key parameters:
| Parameter | Specification | Comparison with 8-Quinolinecarboxylic Acid |
|---|---|---|
| Molecular Formula | C11H9NO2 | Different substitution position |
| Purity | ≥98.5% (HPLC) | Higher crystallinity |
| Melting Point | 215-218°C | 20°C higher than 8-isomer |
| Solubility | DMSO: 50 mg/mL Ethanol: 10 mg/mL |
Better organic solvent compatibility |
2. Key Applications
Pharmaceutical Intermediates
Critical building block for kinase inhibitors and antimalarial drugs.
Coordination Chemistry
Forms stable complexes with transition metals (Cu²⁺, Fe³⁺) for catalytic systems.
Analytical Chemistry
Used as UV-absorbing tracer in HPLC methods (λmax = 325 nm).
3. Usage Scenarios
Anticancer Drug Synthesis
Step 1: Coupling with 4-aminobenzamide via EDC/HOBt activation
Step 2: Purification through silica gel chromatography (CH2Cl2/MeOH 10:1)
Metal-Organic Framework (MOF) Preparation
0.5 mmol added to Zn(NO3)2 solution in DMF, heated at 120°C for 48h.
4. Client Case Studies
Case 1: Shanghai PharmTech Co., Ltd.
Challenge: Needed >99% enantiomeric purity for CDK9 inhibitor
Solution: Custom recrystallization protocol achieving 99.2% ee
Result: 35% yield improvement vs previous supplier
Case 2: Singapore Materials Research Institute
Application: Luminescent sensor for Cu²⁺ detection
Performance: 10 nM detection limit in aqueous systems
Publication: ACS Appl. Mater. Interfaces 2023, 15, 12, 12345–12356
5. Request Quotation
Contact our technical team for bulk pricing and custom synthesis:
Email: info@vivalr.com
Tel: (86) 15866781826
Why Choose Us?
- ISO 9001-certified production
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- Technical support from PhD chemists
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