5-Bromo-2-pyridinecarboxylic Acid Product Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 5-Bromo-2-pyridinecarboxylic Acid | 5-Chloro-2-pyridinecarboxylic Acid |
|---|---|---|
| CAS Number | 73290-19-6 | 374624-24-5 |
| Molecular Formula | C6H4BrNO2 | C6H4ClNO2 |
| Purity Grade | ≥98% (HPLC) | ≥97% (HPLC) |
| Reactivity | Superior bromine-mediated coupling | Moderate chlorination activity |
2. Applications & Industrial Uses
2.1 Pharmaceutical Intermediates
Key building block for kinase inhibitors (EGFR, VEGFR) and antiviral agents.
2.2 Organic Electronic Materials
Precursor for OLED electron transport layers with enhanced thermal stability.
2.3 Agrochemical Development
Core component in novel fungicides targeting cytochrome P450 enzymes.
3. Operational Guidelines & Safety Protocols
| Handling Requirement | Specification |
|---|---|
| PPE | Nitrile gloves, chemical goggles |
| Storage | 2-8°C in amber glass under N2 |
| Shelf Life | 24 months when properly stored |
4. Case Study: Pharmaceutical Intermediate Synthesis
4.1 Project Overview
European pharma company developed third-generation EGFR inhibitor using 5-Bromo-2-pyridinecarboxylic Acid as key intermediate, achieving 92% yield in Suzuki coupling reactions.
4.2 Technical Parameters
| Reaction Scale | 150kg batch |
| Catalyst System | Pd(PPh3)4/K2CO3 |
5. Verified Client Implementations
5.1 ChemFront Laboratories (USA)
Utilized 500kg annually in API synthesis for clinical-stage PARP inhibitor program.
5.2 MateriaNova SA (Belgium)
Developed high-performance liquid crystals for display technologies using brominated pyridine derivatives.
6. Request Customized Solutions
Contact our technical team for batch synthesis, custom derivatization, or regulatory support:
info@vivalr.com
(86) 15866781826
Submit your project requirements for:
- Bulk pricing (100kg+ orders)
- Technical documentation (CoA, MSDS)
- Custom halogenation services
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