6-Fluoronicotinic Acid: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
6-Fluoronicotinic Acid (CAS 403-45-2) is a fluorinated derivative of nicotinic acid, widely used in pharmaceutical and agrochemical synthesis. Key parameters:
| Parameter | Specification | Comparison with Nicotinic Acid |
|---|---|---|
| Molecular Formula | C6H4FNO2 | + Fluorine substituent |
| Purity | ≥98% | Higher reactivity |
| Melting Point | 190-194°C | Improved thermal stability |
2. Key Applications
Pharmaceutical Intermediates
Used in synthesis of fluorinated drug candidates for oncology and CNS diseases.
Agrochemicals
Critical component in next-generation herbicides and fungicides.
Material Science
Building block for fluorinated liquid crystals and OLED materials.
3. Step-by-Step Usage Guidelines
Pharmaceutical Synthesis Example
- Dissolve 6-Fluoronicotinic Acid (1.0 eq) in anhydrous DMF
- Add HATU coupling reagent (1.2 eq) at 0°C
- React with amine component for 4hrs at RT
- Purify via column chromatography (Hex/EA 3:1)
4. Real-World Case Studies
Case 1: Top 10 Pharma Company
Challenge: Develop fluorinated kinase inhibitor
Solution: Used 6-Fluoronicotinic Acid as key intermediate
Result: 22% yield improvement vs non-fluorinated analog
Case 2: Agrochemical Leader
Challenge: Create systemic fungicide
Solution: Incorporated 6-Fluoronicotinic Acid in lead compound
Result: 15x longer soil half-life vs previous formulation
5. Inquiry & Contact
Request custom synthesis or bulk pricing:
- Email: info@vivalr.com
- Tel: (86) 15866781826
MSDS and COA available upon request.
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