1. Product Overview & Specifications

Chemical Name: ((2R,3R,4R)-3-(Benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

CAS No.: 874638-80-9 (varies by synthesis pathway)

Molecular Formula: C₃₁H₂₆FNO₇

Molecular Weight: 547.54 g/mol

Key Parameters Comparison

2. Key Applications

This compound serves as a critical intermediate in antiviral drug synthesis, specifically for:

• Sofosbuvir Production: Key precursor in HCV protease inhibitor manufacturing.
• Nucleotide Analog Development: Enables structural modifications for enhanced bioavailability.
• Antiviral Research: Used in preclinical studies targeting RNA viruses.

3. Usage Guidelines

Handling Protocols

• Use PPE under ISO Class 5 cleanroom conditions
• Stabilize with nitrogen purge during transfers

Synthetic Integration

Typical reaction sequence:

1. Coupling with cytosine derivatives (0-5°C)
2. Phosphoramidate activation (dry THF)
3. Final purification via column chromatography

4. Industry Case Studies

Case 1: API Manufacturer (Shanghai)

Challenge: Scale-up from 10g to 50kg batches with ≥99.5% chiral purity
Solution: Optimized crystallization protocol achieving 99.7% ee
Outcome: 92% yield at commercial scale

Case 2: Research Institute (Beijing)

Challenge: Develop deuterated analogs for metabolic studies
Solution: Modified benzoyl protection strategy
Outcome: Successful PK analysis in murine models

5. Contact for Custom Solutions

Request technical packages or discuss project requirements: