(S)-N-Boc-2-Hydroxymethylmorpholine

Product Name:(S)-N-Boc-2-Hydroxymethylmorpholine
CAS:135065-76-8
MFC10H19NO4
MW:217.26
EINECS:696-348-1
MOL File:135065-76-8.mol

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Comprehensive Guide to (S)-N-Boc-2-Hydroxymethylmorpholine

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter Specification
CAS Number 135065-76-8
Molecular Formula C10H19NO4
Molecular Weight 217.26 g/mol
HS Code (India) 29349900
Synonyms tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate
Boc-(S)-2-Morpholinemethanol
N-Boc-L-Morpholine-2-methanol

Comparative Analysis

Feature (S)-N-Boc-2-Hydroxymethylmorpholine Conventional Morpholine Derivatives
Stereochemical Purity >98% enantiomeric excess Racemic mixtures typical
Thermal Stability Stable up to 150°C Decomposes at 100-120°C

2. Pharmaceutical Applications

2.1 Intermediate in API Synthesis

This chiral building block enables precise construction of:

  • Protease inhibitors for antiviral therapies
  • Kinase inhibitors in oncology treatments
  • Neurological disorder medications

2.2 Asymmetric Catalysis

The stereogenic center facilitates:

  • Enantioselective hydrogenation reactions
  • Chiral auxiliary applications
  • Resolution of racemic mixtures

3. Implementation Case Studies

Case 1: Anticancer Drug Development

PharmaTech Solutions utilized this compound to create a novel PARP inhibitor:

  • Improved synthetic yield by 40% vs previous routes
  • Achieved 99.2% chiral purity in final API
  • Reduced production costs by $28/g in scale-up

Case 2: Continuous Flow Chemistry

ChemicalFlow Systems implemented continuous processing:

Metric Result
Throughput 2.8 kg/day
Process Efficiency 92% conversion rate

4. Client Implementation Examples

Client A: Global Pharma Leader

Application: Hepatitis C protease inhibitor intermediate
Results:

  • Phase III clinical trial material production
  • 99.5% HPLC purity achieved
  • GMP-compliant manufacturing process

Client B: Specialty Chemical Manufacturer

Application: Chiral catalyst development
Achievements:

  • Developed 3 novel catalytic systems
  • Won 2024 Green Chemistry Award
  • Secured 2 international patents

5. Technical Consultation & Ordering

Our experts provide:

  • Regulatory support (REACH, FDA DMF)
  • Custom synthesis capabilities
  • Technical documentation package

Contact our chemistry team:
Email: info@vivalr.com
Phone: (86) 15866781826

Request product specifications:
[Download Safety Data Sheet]
[Request Certificate of Analysis]

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