R-1-(2,6-Dichloro-3-fluorophenyl)ethanol: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
CAS Number: 1029432-75-6
Molecular Formula: C8H6Cl2FOH
Molecular Weight: 225.04 g/mol
Appearance: White to off-white crystalline powder
Comparative Analysis
| Parameter | R-1-(2,6-Dichloro-3-fluorophenyl)ethanol | Similar Chiral Alcohols |
|---|---|---|
| Purity | ≥99% (HPLC) | 95-98% |
| Storage | 2-8°C, inert atmosphere | Room temperature |
| Chiral Purity | ee ≥99.5% | ee 90-95% |
2. Key Applications
Pharmaceutical Intermediates
Widely used in synthesizing chiral active pharmaceutical ingredients (APIs) for:
- Antidepressants
- Antiviral agents
- Kinase inhibitors
Agrochemical Synthesis
Critical precursor for:
- Herbicide intermediates
- Fungicide building blocks
3. Usage Scenarios
Scenario 1: Asymmetric Synthesis
Used as chiral auxiliary in Sharpless epoxidation reactions under controlled conditions (-20°C, nitrogen atmosphere).
Scenario 2: Scale-up Production
Batch process optimization guidelines:
- Recommended solvent: anhydrous THF
- Optimal reaction temperature: 0-5°C
- Typical yield: 82-87%
4. Client Case Studies
Case Study 1: PharmaCorp Ltd.
Challenge: Needed high-purity chiral intermediate for Phase III clinical trial material
Solution: Custom synthesis at 99.8% purity with full chiral resolution
Result: 30% yield improvement vs previous supplier
Case Study 2: AgroSolutions Inc.
Challenge: Required stable supply of GMP-grade material
Solution: 24-month stability program with controlled storage protocols
Result: Zero batch failures in 18-month production window
5. Technical Support & Inquiry
For batch-specific COAs, custom synthesis requests, or technical queries:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request free sample or MSDS: Include your organization name and intended use.


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