2-Chloroquinoline

Product Name:2-Chloroquinoline
CAS:612-62-4
MFC9H6ClN
MW:163.6
EINECS:210-317-8
MOL File:612-62-4.mol

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2-Chloroquinoline User Guide

1. Product Specifications & Comparative Analysis

Parameter 2-Chloroquinoline Typical Halogenated Heterocycles
Chemical Formula C9H6ClN Varies (CnHmXpNq)
CAS Number 612-62-4 N/A
Melting Point 34-37°C 20-150°C (range)
Boiling Point 266-267°C 200-300°C (typical)
Density 1.23 g/mL at 25°C 1.1-1.5 g/mL
Refractive Index 1.6259 (24.6°C) 1.5-1.7

Key Advantages: Higher thermal stability (>230°F flash point) and precise reactivity compared to analogous compounds, making it ideal for controlled synthesis.

2. Applications & Functional Overview

Pharmaceutical Intermediates

  • Core building block for montelukast (anti-asthma drug)
  • Precursor in antispasmodic and antivenom agents

Material Science

  • Electron-deficient component in OLED materials
  • Ligand for transition metal catalysts

Chemical Synthesis

  • Chlorine-directed cross-coupling reactions
  • Nucleophilic substitution reactions (SNAr)

3. Operational Guidelines

Handling Protocols

  • Use PPE: Nitrile gloves, chemical goggles, and lab coat
  • Operate under fume hood with <1 ppm exposure limit

Storage Conditions

  • Temperature: 2-8°C (long-term), RT (short-term)
  • Environment: Dry inert atmosphere (N2 or Ar)
  • Shelf Life: 24 months when properly sealed

4. Case Studies

Case 1: Synthesis of Antimalarial Agents

Used as key intermediate in 8-step synthesis of chloroquine analogues, achieving 78% yield in Buchwald-Hartwig amination.

Case 2: OLED Material Development

Enabled creation of blue-emitting layer with CIE coordinates (0.15, 0.08) and 18% EQE improvement.

5. Client Success Stories

PharmaTech Solutions

  • Application: API intermediate production
  • Outcome: 30% cost reduction in scale-up process
  • Purity Achieved: >99.7% (HPLC)

Advanced Material Labs

  • Application: Conductive polymer synthesis
  • Result: 15% conductivity enhancement
  • Throughput: 500 kg/month

6. Contact for Technical Support

For bulk orders or technical specifications:
Email: info@vivalr.com
Tel: (86) 15866781826

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