2-Chloroquinoline User Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 2-Chloroquinoline | Typical Halogenated Heterocycles |
|---|---|---|
| Chemical Formula | C9H6ClN | Varies (CnHmXpNq) |
| CAS Number | 612-62-4 | N/A |
| Melting Point | 34-37°C | 20-150°C (range) |
| Boiling Point | 266-267°C | 200-300°C (typical) |
| Density | 1.23 g/mL at 25°C | 1.1-1.5 g/mL |
| Refractive Index | 1.6259 (24.6°C) | 1.5-1.7 |
Key Advantages: Higher thermal stability (>230°F flash point) and precise reactivity compared to analogous compounds, making it ideal for controlled synthesis.
2. Applications & Functional Overview
Pharmaceutical Intermediates
- Core building block for montelukast (anti-asthma drug)
- Precursor in antispasmodic and antivenom agents
Material Science
- Electron-deficient component in OLED materials
- Ligand for transition metal catalysts
Chemical Synthesis
- Chlorine-directed cross-coupling reactions
- Nucleophilic substitution reactions (SNAr)
3. Operational Guidelines
Handling Protocols
- Use PPE: Nitrile gloves, chemical goggles, and lab coat
- Operate under fume hood with <1 ppm exposure limit
Storage Conditions
- Temperature: 2-8°C (long-term), RT (short-term)
- Environment: Dry inert atmosphere (N2 or Ar)
- Shelf Life: 24 months when properly sealed
4. Case Studies
Case 1: Synthesis of Antimalarial Agents
Used as key intermediate in 8-step synthesis of chloroquine analogues, achieving 78% yield in Buchwald-Hartwig amination.
Case 2: OLED Material Development
Enabled creation of blue-emitting layer with CIE coordinates (0.15, 0.08) and 18% EQE improvement.
5. Client Success Stories
PharmaTech Solutions
- Application: API intermediate production
- Outcome: 30% cost reduction in scale-up process
- Purity Achieved: >99.7% (HPLC)
Advanced Material Labs
- Application: Conductive polymer synthesis
- Result: 15% conductivity enhancement
- Throughput: 500 kg/month
6. Contact for Technical Support
For bulk orders or technical specifications:
Email: info@vivalr.com
Tel: (86) 15866781826


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