tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

Product Overview: tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

Table of Contents

• 1. Product Specifications & Comparative Analysis
• 2. Applications & Use Cases
• 3. Industry Case Studies
• 4. Client Success Stories
• 5. Request a Quote or Inquiry

1. Product Specifications & Comparative Analysis

2. Applications & Use Cases

Key Applications:

• Suzuki-Miyaura Cross-Coupling: Critical boronated intermediate for synthesizing kinase inhibitors.
• Pharmaceutical Intermediates: Used in the development of anticancer and anti-inflammatory drugs.
• PROTAC Molecules: Enables targeted protein degradation in oncology research.

3. Industry Case Studies

Case Study 1: Kinase Inhibitor Optimization

• Challenge: Low yield in coupling reactions due to unstable boronic ester intermediates.
• Solution: Implementation of tert-butyl-protected piperidine-boronate for enhanced stability.
• Result: 40% increase in reaction efficiency and 99% purity in final API.

4. Client Success Stories

Client A: PharmaCorp (USA)

• Project: Development of a third-generation EGFR inhibitor.
• Usage: Served as a key intermediate in the synthesis of the boronate-containing core structure.
• Outcome: Accelerated preclinical timeline by 6 months; IND submitted in 2024.

Client B: BioHealth Innovations (Germany)

• Project: Creation of a BTK-targeting PROTAC molecule.
• Usage: Integrated into the linker region for improved solubility and bioavailability.
• Outcome: Achieved 80% target degradation at 10 nM concentration in vivo.

5. Request a Quote or Inquiry

For pricing, bulk orders, or technical documentation:

• Email: info@vivalr.com
• Phone: (86) 15866781826

Our team provides:

• Custom synthesis up to kilogram scale
• GMP-grade production for clinical trials
• Regulatory support (DMF, CMC documentation)