(S)-(+)-Glycidyl Phthalimide

Product Name:(S)-(+)-Glycidyl Phthalimide
CAS:161596-47-0
MFC11H9NO3
MW:203.19
EINECS:454-720-9
MOL File:161596-47-0.mol

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Comprehensive Guide to (S)-(+)-Glycidyl Phthalimide: Applications, Case Studies & Technical Insights

1. Product Overview & Specifications

Technical Parameters

Parameter Specification Competitor A Competitor B
Chemical Name (S)-(+)-Glycidyl Phthalimide Racemic Mixture Undisclosed Isomer
CAS Number 6296-87-1 N/A N/A
Purity ≥99.5% (HPLC) 98.0-99.0% 97.5%
Optical Rotation [α]D²⁰ = +15° to +18° Not Specified ±5° Range

2. Key Applications & Industrial Uses

Pharmaceutical Intermediate

Enables stereoselective synthesis of β-blocker APIs including:

  • Propranolol hydrochloride
  • Metoprolol succinate
  • Atenolol derivatives

Advanced Polymer Chemistry

Critical component for:

  • Epoxy resin cross-linking (Tg enhancement up to 25°C)
  • Photoresist formulations (248nm lithography compliance)
  • Dielectric materials (Dk ≤2.7 @ 10GHz)

3. Operational Guidelines & Best Practices

Storage Protocol

  • Maintain at 2-8°C under inert atmosphere
  • Max moisture content: 0.15% (Karl Fischer)

Reaction Parameters

Application Solvent Temperature Yield
Epoxy Curing THF/DMF (4:1) 60-70°C 92-95%
API Synthesis Anhydrous Ethanol Reflux 86-89%

4. Implementation Case Studies

Case 1: High-Performance Aerospace Adhesive

Challenge: Develop epoxy with Tg >180°C and CTE <50 ppm/°C

Solution: 15% (w/w) loading in DGEBA matrix

Result: Achieved Tg 192°C (DSC), peel strength 8.2 N/mm

Case 2: Antihypertensive Drug Synthesis

Challenge: Improve enantiomeric excess (ee) from 92% to >99%

Solution: Chiral resolution using (S)-(+)-isomer

Result: 99.3% ee achieved (HPLC), reduced side products by 67%

5. Client Success Stories

PharmaCo Solutions Ltd. (UK)

Project: Scale-up of carvedilol intermediate

Outcome: Achieved 2.3 MT/month production with 99.1% purity

Advanced Materials Inc. (USA)

Application: Underfill encapsulant for 5G MMICs

Results: εr 3.2 @ 28GHz, passed MIL-STD-883H

6. Request Customized Solutions

Contact our technical team for formulation support or bulk pricing:

info@vivalr.com

(86) 15866781826

✉️ Request SDS & COA Documents

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