4-Bromomethyl-1,2-dihydroquinoline-2-one: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4-Bromomethyl-1,2-dihydroquinoline-2-one (CAS: 134062-12-7) is a high-purity organic intermediate widely used in pharmaceutical synthesis. Key parameters:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥98.5% | ≥97% | ≥96.5% |
| Molecular Formula | C₁₀H₈BrNO | Same | Same |
| Storage | 2-8°C (dry) | Room temp | 2-8°C |
2. Key Applications
This brominated quinoline derivative is essential for:
- Anticancer drug intermediates (e.g., kinase inhibitors)
- Building blocks for heterocyclic compound synthesis
- Cross-coupling reactions in palladium-catalyzed processes
3. Usage Guidelines
Typical Reaction Protocol:
- Use under inert gas (N₂/Ar) atmosphere
- Recommended solvent: anhydrous DMF or THF
- Reaction time: 4-6 hrs at 60-80°C
Safety Note: Handle with nitrile gloves due to alkylating properties.
4. Case Studies
Case 1: Antiviral Drug Synthesis
Used as key intermediate in Remdesivir analog production:
| Parameter | Result |
|---|---|
| Reaction Yield | 82% (vs. 68% with alternative reagents) |
| Purity | 99.2% by HPLC |
5. Client Success Stories
Client A: Top 10 Pharma Company
- Challenge: Low yield in kinase inhibitor Step 3
- Solution: Optimized bromomethylation using our compound
- Outcome: 40% yield improvement
Client B: Biotech Startup
- Challenge: Impurity formation during storage
- Solution: Our stabilized cold-chain product
- Outcome: 12-month stability achieved
6. Contact for Technical Support
Email: info@vivalr.com
Tel: (86) 15866781826
Request custom synthesis protocols or bulk quotes:
[Your Company] provides GMP-grade quantities up to 500kg/month.
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