6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE

Comprehensive Guide to 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE

1. Product Overview & Specifications

6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE (CAS: 942320-42-7) is a heterocyclic compound with molecular formula C₇H₄ClN₃. This pharmaceutical intermediate exhibits high purity levels (≥98%) and stability under controlled storage conditions.

2. Key Applications

Primary applications in pharmaceutical development:

• Kinase inhibitor intermediates
• Anticancer drug candidates
• JAK/STAT signaling pathway modulators
• Organic light-emitting diode (OLED) materials

3. Usage Guidelines

Handling Protocols:

1. Use nitrogen atmosphere for sensitive reactions
2. Recommended solvent: anhydrous DMF
3. Optimal reaction temperature: 0-5°C

4. Industry Case Studies

Case 1: Oncology Drug Development
A Top 20 Pharma company utilized this intermediate in Phase II trials for non-small cell lung cancer treatment, achieving 92% reaction yield in key coupling steps.

5. Verified Client Implementations

Client A: EuroChem Solutions
– Application: JAK1 inhibitor production
– Quantity: 15kg batch order
– Result: Reduced synthesis steps from 7 to 4
– Feedback: “Improved overall yield by 18%”

Client B: BioSyntech GmbH
– Application: BTK inhibitor research
– Implementation: Scaled from 100g to 5kg production
– Outcome: Achieved 99.2% HPLC purity

6. Request Custom Solutions

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