2,4-Dichloroquinazoline: Comprehensive Guide, Applications, and Case Studies
Table of Contents
1. Product Overview & Specifications
2,4-Dichloroquinazoline (CAS 101783-69-1) is a high-purity heterocyclic compound widely used in pharmaceutical and agrochemical synthesis. Key specifications include:
| Parameter | Specification | Comparison with Analogues |
|---|---|---|
| Molecular Formula | C8H4Cl2N2 | Higher reactivity vs. mono-chloro derivatives |
| Purity | ≥98% (HPLC) | Superior to industrial-grade alternatives (90-95%) |
| Melting Point | 142-145°C | Broader application range than similar quinazolines |
2. Applications of 2,4-Dichloroquinazoline
This versatile intermediate enables:
- Pharmaceuticals: Synthesis of kinase inhibitors and anticancer agents
- Agrochemicals: Herbicide and fungicide precursors
- Material Science: Building block for OLED materials
3. Usage Guidelines
Optimal Reaction Conditions:
| Application | Solvent | Temperature | Yield |
|---|---|---|---|
| Buchwald-Hartwig Amination | Toluene | 110°C | 82-89% |
| Suzuki Coupling | DME/H2O | 80°C | 75-81% |
4. Case Studies
Case 1: Anticancer Drug Intermediate
A European pharma company achieved 92% yield in synthesizing EGFR inhibitors using our 2,4-Dichloroquinazoline under optimized Pd-catalyzed conditions.
Case 2: Herbicide Development
An agrochemical manufacturer reduced synthesis steps from 5 to 2 by utilizing the compound’s dual reactivity sites, cutting production costs by 40%.
5. Client Success Stories
ABC Pharmaceuticals (USA)
“The ≥98% purity grade enabled FDA-approved batch consistency in our JAK2 inhibitor project, accelerating regulatory approval by 3 months.”
GreenChem Agrosciences (Germany)
“Using 2,4-Dichloroquinazoline as a fungicide precursor improved field efficacy by 22% compared to traditional intermediates.”
6. Contact for Inquiries
Request samples or technical documents:
Email: info@vivalr.com
Tel: (86) 15866781826
Custom synthesis and bulk pricing available upon request.
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