2-Fluoro-5-Hydroxypyridine: Comprehensive User Guide for Researchers and Industry Professionals
Table of Contents
1. Product Overview & Key Parameters
| Parameter | Specification |
|---|---|
| CAS Number | 107519-08-4 |
| Molecular Formula | C5H4FNO |
| Purity | ≥98% (HPLC) |
| Melting Point | 148-152°C |
| Storage | 2-8°C in inert atmosphere |
2. Applications in Pharmaceutical & Chemical Industries
2-Fluoro-5-hydroxypyridine serves as critical building block in:
- Anticancer drug intermediates
- Kinase inhibitor development
- PET radiotracer synthesis
- Agrochemical precursors
- Coordination chemistry ligands
3. Usage Guidelines & Safety Protocols
Handling Recommendations:
- Use under nitrogen atmosphere for moisture-sensitive reactions
- Optimal solubility: DCM/THF (1:1) at 40°C
- Incompatible with strong oxidizers
4. Industry Case Studies
Case 1: Oncology Drug Development
Client: Top 10 Pharma Company (Confidential)
- Application: Third-generation EGFR inhibitor synthesis
- Result: Improved reaction yield from 62% to 89%
- Scale: 150kg batch production
Case 2: Agricultural Chemistry
Client: European Agrochemical Producer
- Application: Novel neonicotinoid analogue
- Result: Achieved 99.2% regioselectivity
- Outcome: Patent filed (WO2022154321A1)
5. Technical Comparison with Analogues
| Compound | Reactivity | Stability | Cost Efficiency |
|---|---|---|---|
| 2-F-5-OH-Pyridine | High | Excellent | ★★★★☆ |
| 3-F-4-OH-Pyridine | Moderate | Good | ★★★☆☆ |
| 5-F-2-OH-Pyridine | Low | Fair | ★★☆☆☆ |
6. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (100kg+ orders)
- Custom fluorination services
- Regulatory support (REACH, TSCA)
Email: info@vivalr.com
Tel: (86) 15866781826
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