2-Chloro-5-iodopyridine

2-Chloro-5-iodopyridine: Comprehensive User Guide

Product Overview

2-Chloro-5-iodopyridine (CAS 0) is a halogenated pyridine derivative widely used in pharmaceutical intermediates, agrochemical synthesis, and material science. Its molecular formula is C₅H₃ClIN, with a molecular weight of 284.45 g/mol.

Key Parameters & Specifications

Applications & Use Cases

Pharmaceutical Intermediates

Used in Suzuki-Miyaura cross-coupling reactions to synthesize kinase inhibitors for cancer therapy.

Agrochemical Synthesis

Key intermediate in fungicides targeting cytochrome bc1 complex inhibition.

Material Science

Building block for conductive polymers in OLED devices.

Detailed Usage Examples

Suzuki Coupling Protocol

1. Mix 2-Chloro-5-iodopyridine (1 eq) with boronic acid (1.2 eq)
2. Add Pd(PPh₃)₄ (0.05 eq) in degassed toluene/EtOH (3:1)
3. Heat at 80°C under N₂ for 12 hours

Client Success Stories

Case 1: InnovatePharma Solutions

• Challenge: Low yield in JAK2 inhibitor synthesis
• Solution: Optimized coupling using 99% purity 2-Chloro-5-iodopyridine
• Result: Yield increased from 45% to 82%

Case 2: AgroGuard Ltd.

• Challenge: Impurity formation during fungicide production
• Solution: Switched to our ≥99% grade material
• Result: API purity improved to 99.7%

Inquiry & Contact

Request custom synthesis or bulk pricing:

• Email: info@vivalr.com
• Phone: (86) 15866781826