4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

1. Product Overview & Specifications

4-Bromo-pyridine-2-carboxylic Acid Methyl Ester (CAS 102003-75-6) is a brominated pyridine derivative widely used in pharmaceutical intermediates and agrochemical synthesis.

2. Key Applications

This compound serves as critical building block in:

• Pharmaceutical intermediates for kinase inhibitors
• Agrochemical active ingredients
• Ligand synthesis in catalysis

Its bromine substituent enables efficient cross-coupling reactions in API development.

3. Usage Guidelines

Storage: Maintain at 2-8°C in original container under inert atmosphere.

Handling: Use PPE and conduct reactions in well-ventilated fume hoods due to potential bromine release at elevated temperatures.

4. Case Studies

Case 1: Anticancer Drug Intermediate Synthesis

Used in Buchwald-Hartwig amination to produce PARP inhibitor precursors with 92% yield improvement over chloro-analogues.

Case 2: Herbicide Formulation

Enabled synthesis of novel pyridine-based herbicides showing 40% higher field efficacy compared to traditional compounds.

5. Client Success Stories

PharmaTech Solutions (Germany)

Achieved 30% cost reduction in Phase III clinical trial materials through optimized coupling reactions using our product.

AgroNova Ltd (USA)

Developed patent-protected fungicide using our compound as key intermediate, accelerating time-to-market by 18 months.

Material Science Innovations (Japan)

Created high-performance OLED materials with 15% increased luminous efficiency through bromine-directed crystallization.