2-Hydroxy-3-trifluoromethylpyridine: Technical Guide & Industry Applications
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification | Competitor Compound A | Competitor Compound B |
|---|---|---|---|
| Chemical Name | 2-Hydroxy-3-(trifluoromethyl)pyridine | 3-Trifluoromethylpyridin-2-ol | 5-Trifluoromethylpyridin-2-ol |
| CAS Number | 131747-57-8 | N/A | 89402-27-7 |
| Molecular Formula | C₆H₄F₃NO | C₆H₄F₃NO | C₆H₄F₃NO |
| Purity | ≥99.5% (HPLC) | ≥98% | ≥97% |
| Storage Conditions | 2-8°C in inert atmosphere | Room temperature | 4-25°C |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediate: Critical component in synthesizing:
- JAK3 inhibitors for autoimmune diseases
- FLT3 kinase inhibitors for leukemia treatment
- Antimicrobial agents with enhanced bioavailability
Agrochemical Applications:
- Key precursor for next-gen herbicides
- Stable fluorinated structure improves pesticide longevity
3. Usage Guidelines & Best Practices
Suzuki-Miyaura Cross-Coupling Protocol:
- Charge reaction vessel with 1.2 eq of boronic acid
- Maintain nitrogen atmosphere throughout process
- Use Pd(PPh₃)₄ catalyst (0.05 mol%)
- Optimized reaction temperature: 80-85°C
4. Industry Case Studies
Case 1: Top 10 Pharma Company (2024)
- Application: Development of novel kinase inhibitor
- Result: 38% yield improvement vs previous intermediates
- Scale: 150kg batch production
Case 2: European Crop Science Leader
- Application: Systemic herbicide formulation
- Result: 92% weed control efficacy at 50g/ha
- Regulatory: EPA/FDA compliance achieved
5. Comparative Analysis
| Property | 2-Hydroxy-3-TFMpyridine | 3-Hydroxy-5-TFMpyridine |
|---|---|---|
| Water Solubility | 1.2g/L @25°C | 0.8g/L @25°C |
| Melting Point | 89-92°C | 102-105°C |
| Catalytic Efficiency | 92% yield | 78% yield |
6. Technical Consultation & Ordering
For formulation support or bulk pricing:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request SDS, COA, or custom synthesis options.
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