Comprehensive Guide to 5-Bromopyrimidine: Properties, Applications, and Supplier Insights
Table of Contents
1. Product Overview & Key Specifications
5-Bromopyrimidine (CAS 4595-60-4), a halogenated heterocyclic compound, serves as critical building block in organic synthesis. Technical parameters:
| Parameter | Specification |
|---|---|
| Molecular Formula | C4H3BrN2 |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Melting Point | 89-92°C |
| Storage | 2-8°C in inert atmosphere |
Grade Comparison
| Grade | Pharma | Industrial | Research |
|---|---|---|---|
| Purity | ≥99.5% | ≥97% | ≥95% |
| Packaging | 1kg amber bottles | 25kg drums | 100g vials |
| Lead Time | 4-6 weeks | 2-3 weeks | 1 week |
2. Industrial Applications of 5-Bromopyrimidine
Pharmaceutical Intermediate
Key precursor in:
- Kinase inhibitor development (EGFR, BTK)
- Anticancer drug candidates
- Antiviral compound synthesis
Agrochemical Synthesis
Essential for:
- Herbicidal pyrimidine derivatives
- Fungicide intermediates
- Plant growth regulators
Material Science
- OLED electron transport materials
- Coordination polymer frameworks
3. Technical Comparison of Commercial Grades
| Supplier | Purity | Price/kg | MOQ |
|---|---|---|---|
| Supplier A | 99.8% | $1,850 | 5kg |
| Supplier B | 98.5% | $1,250 | 25kg |
| Supplier C | 97.0% | $980 | 100kg |
4. Operational Guidelines & Safety Protocols
Handling Procedures
- Use NIOSH-approved respirators
- Maintain inert atmosphere during transfer
- Ground all equipment
Reaction Optimization
- Optimal coupling conditions: Pd(PPh3)4, 80°C
- Purification: Column chromatography (Hexane/EA)
5. Case Studies: Real-World Implementations
Case 1: Oncology Drug Development
Client: Top 10 Pharma Company
- Application: BTK inhibitor intermediate
- Scale: 200kg/month
- Yield Improvement: 22% through optimized bromination
Case 2: Agrochemical Innovation
Client: Agrochemical Leader
- Usage: Fungicidal pyrimidine ethers
- Result: 40% cost reduction vs traditional routes
Case 3: OLED Material Production
Client: Display Materials Manufacturer
- Implementation: Electron transport layer
- Performance: 15% efficiency gain
6. Strategic Procurement Considerations
Supplier Evaluation Matrix
| Factor | Weight | Evaluation Criteria |
|---|---|---|
| Quality Consistency | 35% | Batch-to-batch HPLC analysis |
| Supply Reliability | 30% | On-time delivery history |
| Technical Support | 20% | Synthesis optimization assistance |
| Cost Competitiveness | 15% | Total cost of ownership |
Contact Our Experts
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