2-Bromo-3-chloro-5-(trifluoromethyl)pyridine

Product Name:2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
CAS:75806-84-7
MFC6H2BrClF3N
MW:260.44
EINECS:
MOL File:75806-84-7.mol

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2-Bromo-3-chloro-5-(trifluoromethyl)pyridine: Comprehensive User Guide

1. Product Overview & Specifications

2-Bromo-3-chloro-5-(trifluoromethyl)pyridine (CAS 89402-26-0) is a halogenated pyridine derivative widely used in pharmaceuticals, agrochemicals, and material science. Key specifications include:

Parameter Value
Molecular Formula C6H2BrClF3N
Molecular Weight 259.44 g/mol
Appearance White to pale yellow crystalline powder
Purity ≥98% (HPLC)
Storage 2-8°C in airtight containers

2. Applications & Use Cases

Pharmaceutical Intermediates

Used in synthesizing kinase inhibitors and antiviral agents due to its electron-withdrawing trifluoromethyl group, enhancing binding affinity.

Agrochemicals

Key intermediate for herbicides and insecticides, offering improved metabolic stability in crop protection formulations.

Material Science

Facilitates development of liquid crystals and OLED materials via Suzuki-Miyaura cross-coupling reactions.

3. Comparative Analysis

Compound Reactivity Stability Cost Efficiency
2-Bromo-3-chloro-5-(trifluoromethyl)pyridine High (Br/Cl activation) Excellent $$$
2-Chloro-5-(trifluoromethyl)pyridine Moderate Good $$
3-Bromo-5-(trifluoromethyl)pyridine Medium Thermally sensitive $$$

4. Real-World Customer Case Studies

Case Study 1: ABC Pharma

Challenge: Required high-purity intermediate for a Bruton’s tyrosine kinase (BTK) inhibitor.
Solution: Custom synthesis with ≥99% purity achieved via optimized palladium-catalyzed amination.
Outcome: 22% yield improvement over previous bromopyridine analogs.

Case Study 2: AgroChem Solutions

Challenge: Needed stable pyridine derivative for soil-persistent herbicide.
Solution: Formulation with 2-Bromo-3-chloro-5-TFM-pyridine showed 18-month shelf-life.
Outcome: Reduced application frequency by 40% in field trials.

5. Contact for Customized Solutions

Optimize your synthesis with our technical expertise:

info@vivalr.com
(86) 15866781826

Request COA, MSDS, or custom synthesis protocols today.

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