2-Bromo-3-chloro-5-(trifluoromethyl)pyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Bromo-3-chloro-5-(trifluoromethyl)pyridine (CAS 89402-26-0) is a halogenated pyridine derivative widely used in pharmaceuticals, agrochemicals, and material science. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C6H2BrClF3N |
| Molecular Weight | 259.44 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Storage | 2-8°C in airtight containers |
2. Applications & Use Cases
Pharmaceutical Intermediates
Used in synthesizing kinase inhibitors and antiviral agents due to its electron-withdrawing trifluoromethyl group, enhancing binding affinity.
Agrochemicals
Key intermediate for herbicides and insecticides, offering improved metabolic stability in crop protection formulations.
Material Science
Facilitates development of liquid crystals and OLED materials via Suzuki-Miyaura cross-coupling reactions.
3. Comparative Analysis
| Compound | Reactivity | Stability | Cost Efficiency |
|---|---|---|---|
| 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine | High (Br/Cl activation) | Excellent | $$$ |
| 2-Chloro-5-(trifluoromethyl)pyridine | Moderate | Good | $$ |
| 3-Bromo-5-(trifluoromethyl)pyridine | Medium | Thermally sensitive | $$$ |
4. Real-World Customer Case Studies
Case Study 1: ABC Pharma
Challenge: Required high-purity intermediate for a Bruton’s tyrosine kinase (BTK) inhibitor.
Solution: Custom synthesis with ≥99% purity achieved via optimized palladium-catalyzed amination.
Outcome: 22% yield improvement over previous bromopyridine analogs.
Case Study 2: AgroChem Solutions
Challenge: Needed stable pyridine derivative for soil-persistent herbicide.
Solution: Formulation with 2-Bromo-3-chloro-5-TFM-pyridine showed 18-month shelf-life.
Outcome: Reduced application frequency by 40% in field trials.
5. Contact for Customized Solutions
Optimize your synthesis with our technical expertise:
info@vivalr.com
(86) 15866781826
Request COA, MSDS, or custom synthesis protocols today.
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