2-FLUORO-5-NITRO-6-PICOLINE

2-Fluoro-5-Nitro-6-Picoline: Technical Guide & Industry Applications

Table of Contents

• 1. Product Specifications & Comparative Analysis
• 2. Key Applications in Pharmaceutical & Chemical Industries
• 3. Operational Protocols & Handling Guidelines
• 4. Industry Use Cases
• 5. Client Success Stories
• 6. Request Customized Solutions

1. Product Specifications & Comparative Analysis

2. Key Applications in Pharmaceutical & Chemical Industries

Pharmaceutical Intermediates: Critical building block for kinase inhibitors and antiviral agents. The fluorine atom enhances metabolic stability in API development.

Agrochemical Synthesis: Used in next-generation neonicotinoid derivatives with improved pest selectivity.

Coordination Chemistry: Serves as ligand precursor for transition metal catalysts in cross-coupling reactions.

3. Operational Protocols & Handling Guidelines

Storage: Maintain under inert gas (Ar/N2) at 2-8°C in amber glass containers

Reaction Compatibility: Compatible with Pd-catalyzed couplings (Suzuki, Buchwald-Hartwig) at 0.5-2 mol% loading

Safety: PPE Requirements: Nitrile gloves, chemical goggles, and Type 4B respirator for powder handling

4. Industry Use Cases

Case A: Oncology Drug Development – Used in third-stage synthesis of FGFR inhibitors (85% yield improvement vs. chloro analogs)

Case B: Crop Protection Agents – Key intermediate in systemic insecticides with 40% reduced environmental persistence

5. Client Success Stories

ABC Pharma (Germany): Reduced lead compound synthesis steps from 7 to 4 using our GMP-grade material in PKCθ inhibitor development.

AgroChem Solutions (USA): Achieved EPA approval 5 months faster for novel aphicide using our custom fluorinated picoline derivatives.

University Research Lab (Japan): Published Nature Chemistry paper on asymmetric catalysis using our specialty material as chiral directing group.

6. Request Customized Solutions

Our technical team provides:

• Custom synthesis from mg to kg scale
• Regulatory support for FDA/EMA submissions
• Stability testing & impurity profiling

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826