4-Bromo-3-methylpyridine: Technical Guide & Application Insights
Table of Contents
- Product Specifications & Comparative Analysis
- Industrial Applications & Functional Mechanisms
- Operational Protocols & Safety Guidelines
- Case Study 1: Pharmaceutical Intermediate Synthesis
- Case Study 2: Agrochemical Formulation Development
- Case Study 3: Advanced Material Research
- Expert Consultation & Custom Synthesis Services
1. Product Specifications & Comparative Analysis
| Parameter | 4-Bromo-3-methylpyridine | 3-Bromo-4-methylpyridine | 4-Bromo-2-methylpyridine |
|---|---|---|---|
| CAS Number | 3430-28-6 | 3430-27-5 | 5466-48-6 |
| Molecular Formula | C6H6BrN | C6H6BrN | C6H6BrN |
| Melting Point | 32-34°C | 28-30°C | 45-47°C |
| Boiling Point | 215-217°C | 208-210°C | 225-227°C |
2. Industrial Applications & Functional Mechanisms
This heterocyclic compound demonstrates three primary industrial utilities:
- Pharmaceutical Building Block: Enables synthesis of kinase inhibitors through Suzuki coupling reactions
- Agrochemical Precursor: Modifies pesticide bioactivity via nucleophilic substitution
- Coordination Chemistry: Serves as ligand in catalytic systems (Pd/Cu-mediated cross-couplings)
3. Operational Protocols & Safety Guidelines
| Process Stage | Recommended Practice | Hazard Control |
|---|---|---|
| Storage | Argon atmosphere at -20°C | Moisture-sensitive; use sealed amber vials |
| Handling | Glove box operation | Skin corrosion (Category 1B) |
4. Case Study 1: Pharmaceutical Intermediate Synthesis
Client: Top 10 Global Pharma Company (Confidential)
- Application: EGFR inhibitor development for NSCLC treatment
- Technical Challenge: Achieving >98% regioselectivity in bromination
- Solution: Optimized Pd-mediated C-H activation protocol
5. Case Study 2: Agrochemical Formulation Development
Client: European Crop Protection Leader
- Application: Systemic insecticide against aphids
- Technical Challenge: Enhancing soil mobility properties
- Solution: Designed methyl-bromo-pyridine hybrid molecules
6. Case Study 3: Advanced Material Research
Client: US National Laboratory Consortium
- Application: Conductive polymer matrices
- Technical Challenge: Controlling π-π stacking distances
- Solution: Bromine substitution-mediated crystal engineering
7. Expert Consultation & Custom Synthesis Services
Contact our technical team for:
- Bulk synthesis (Kilogram to Ton scale)
- Isomer purity optimization (HPLC >99.9%)
- Regulatory support (REACH, TSCA compliance)
Email: info@vivalr.com
Tel: (86) 15866781826
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