2-Bromo-4-cyanopyridine

Product Name:2-Bromo-4-cyanopyridine
CAS:10386-27-3
MFC6H3BrN2
MW:183.01
EINECS:
MOL File:10386-27-3.mol

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2-Bromo-4-cyanopyridine: Comprehensive User Guide

1. Product Overview & Specifications

2-Bromo-4-cyanopyridine (CAS: 10386-27-3) is a halogenated pyridine derivative with the molecular formula C6H3BrN2 and a molecular weight of 183.01 g/mol. It is widely used in pharmaceutical intermediates and organic synthesis.

Parameter Specification
Purity ≥95% (TRC), ≥99% (Pharmaceutical Grade)
Packaging 1g, 5g, 25g, 500g, 2.5kg (Customizable)
Appearance White to off-white crystalline powder
Storage 2-8°C, dry, protected from light

Supplier Comparison

Supplier Brand Purity Packaging
TRC (Canada) TRC 95% 500mg, 2.5g
BIDU Chemicals (Hubei) BIDU 99% 1kg, 5kg, 25kg
Shanghai Xinyu Bio Millipore N/A Custom

2. Key Applications

2-Bromo-4-cyanopyridine serves as a versatile building block in:

  • Pharmaceuticals: Synthesis of kinase inhibitors, antiviral agents, and anticancer drugs.
  • Agrochemicals: Intermediate for herbicides and fungicides.
  • Material Science: Precursor for functionalized polymers and ligands.

3. Usage Guidelines

  • Handle under inert gas (e.g., nitrogen) to prevent degradation.
  • Use personal protective equipment (gloves, goggles) due to toxicity risks.
  • Optimize reaction conditions (temperature: 80-120°C; solvents: DMF, THF).

4. Case Studies

Case 1: Antiviral Drug Intermediate

A leading pharmaceutical company used 2-bromo-4-cyanopyridine to synthesize a key intermediate for a protease inhibitor, achieving 92% yield via Suzuki-Miyaura coupling.

Case 2: Agrochemical Development

2-Bromo-4-cyanopyridine was functionalized to create a novel fungicide with broad-spectrum activity against Fusarium species.

5. Customer Success Stories

Customer A: Global CRO

Integrated 2-bromo-4-cyanopyridine into high-throughput screening for kinase targets, reducing lead optimization time by 30%.

Customer B: Specialty Chemical Manufacturer

Scaled up production of a boron-containing derivative (CAS: 75927-49-0) using 2-bromo-4-cyanopyridine, achieving ISO 9001 certification.

6. Contact for Quotations

For pricing, technical data sheets, or custom synthesis inquiries:

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