3-Bromo-4-chloropyridine

Product Name：3-Bromo-4-chloropyridine
CAS：36953-42-1
MFC5H3BrClN
MW：192.44
EINECS：690-646-5
MOL File：36953-42-1.mol

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3-Bromo-4-chloropyridine: Comprehensive Product Guide

Parameter	3-Bromo-4-chloropyridine	2-Bromo-3-chloropyridine	4-Bromo-2-chloropyridine
CAS Number	NA	NA	NA
Molecular Formula	C5H3BrClN	C5H3BrClN	C5H3BrClN
Purity	>98% (HPLC)	>97%	>95%
Storage	2-8°C (desiccated)	Ambient	Ambient
Key Advantage	Superior regioselectivity in cross-coupling reactions	Lower cost	Higher thermal stability

Critical building block for kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents. Enables precise functionalization at C3/C4 positions.

Used in neonicotinoid derivatives and fungicide development. Demonstrates 30% higher bioactivity than non-halogenated analogs in field trials.

Key precursor for conducting polymers in OLED devices. Enables tunable electron-withdrawing properties in π-conjugated systems.

Reaction with phenylboronic acid (Pd(PPh3)4, K2CO3, DMF/H2O) yielded 4-chloro-3-phenylpyridine (82% yield).

Cross-coupling with morpholine (Xantphos-Pd catalyst) achieved 93% conversion rate under microwave conditions.

“Used in Phase III oncology drug candidate synthesis. Achieved 99.2% purity in final API, reducing purification costs by 40%.”

“Developed next-gen fungicide with 50% lower application rates using 3-Bromo-4-chloropyridine derivatives.”

“Created OLED emitter layer with 15% improved luminous efficiency through controlled halogen substitution patterns.”

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类别 chem