Product Name：3-Bromo-4-chloropyridine
CAS：36953-42-1
MFC5H3BrClN
MW：192.44
EINECS：690-646-5
MOL File：36953-42-1.mol
| Parameter | 3-Bromo-4-chloropyridine | 2-Bromo-3-chloropyridine | 4-Bromo-2-chloropyridine |
|---|---|---|---|
| CAS Number | NA | NA | NA |
| Molecular Formula | C5H3BrClN | C5H3BrClN | C5H3BrClN |
| Purity | >98% (HPLC) | >97% | >95% |
| Storage | 2-8°C (desiccated) | Ambient | Ambient |
| Key Advantage | Superior regioselectivity in cross-coupling reactions | Lower cost | Higher thermal stability |
Critical building block for kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents. Enables precise functionalization at C3/C4 positions.
Used in neonicotinoid derivatives and fungicide development. Demonstrates 30% higher bioactivity than non-halogenated analogs in field trials.
Key precursor for conducting polymers in OLED devices. Enables tunable electron-withdrawing properties in π-conjugated systems.
Reaction with phenylboronic acid (Pd(PPh3)4, K2CO3, DMF/H2O) yielded 4-chloro-3-phenylpyridine (82% yield).
Cross-coupling with morpholine (Xantphos-Pd catalyst) achieved 93% conversion rate under microwave conditions.
"Used in Phase III oncology drug candidate synthesis. Achieved 99.2% purity in final API, reducing purification costs by 40%."
"Developed next-gen fungicide with 50% lower application rates using 3-Bromo-4-chloropyridine derivatives."
"Created OLED emitter layer with 15% improved luminous efficiency through controlled halogen substitution patterns."
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