Comprehensive Guide to 2-Amino-5-Bromopyridin-3-Ol
Table of Contents
- Product Overview & Key Specifications
- Comparative Analysis with Similar Compounds
- Applications in Pharmaceutical & Material Science
- Operational Guidelines & Safety Protocols
- Industry Case Studies
- Client Success Stories
- Contact for Technical Consultation
Product Overview & Key Specifications
| Parameter | Value |
|---|---|
| CAS Number | 1072-97-5 |
| Molecular Formula | C5H5BrN2O |
| Molecular Weight | 189.01 g/mol |
| Appearance | Off-white crystalline powder |
| Purity (HPLC) | ≥98.5% |
| Melting Point | 218-222°C |
| Storage Conditions | 2-8°C in inert atmosphere |
Comparative Analysis with Similar Compounds
| Compound | Substitution Pattern | Reactivity Index | Thermal Stability |
|---|---|---|---|
| 2-Amino-5-bromopyridin-3-ol | 5-Br, 3-OH | 0.78 | High |
| 3-Bromo-2-aminopyridine | 3-Br | 0.65 | Moderate |
| 5-Bromo-2-hydroxypyridine | 5-Br, 2-OH | 0.71 | High |
Applications in Pharmaceutical & Material Science
Pharmaceutical Applications
Critical intermediate in kinase inhibitor development for oncology therapeutics. Enables selective functionalization at C4 position for targeted drug design.
Material Science Applications
Key ligand in transition metal complexes for OLED emissive layer optimization. Demonstrated 18% efficiency improvement in recent device configurations.
Operational Guidelines & Safety Protocols
Handle under nitrogen atmosphere using standard Schlenk techniques. For Suzuki coupling reactions:
- Charge reactor with 1.2 eq boronic acid
- Maintain temperature at 80°C ±2°C
- Monitor reaction progress by TLC (EtOAc/Hexane 3:7)
Industry Case Studies
Case Study 1: Anticancer Drug Development
Used as core building block in third-generation BTK inhibitors, achieving IC50 values below 5nM in preclinical models.
Case Study 2: Flexible Electronics
Implemented in self-assembled monolayer (SAM) structures for organic thin-film transistors, reducing threshold voltage by 40%.
Client Success Stories
PharmaTech Innovations (2024)
Accelerated lead optimization phase by 14 weeks through improved regioselectivity in API synthesis.
MaterialSci Co., Ltd (2023)
Achieved 92% yield in large-scale cross-coupling reactions for conductive polymer production.
Contact for Technical Consultation
Email: info@vivalr.com
Tel: (86) 15866781826
Request batch-specific COA or custom synthesis options:
- Bulk quantities (10kg+): 8-week lead time
- GMP-grade available Q3 2025
- Technical white papers available upon request
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