Comprehensive Guide to 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
Table of Contents
- Product Overview & Specifications
- Applications & Use Cases
- Case Studies: Real-World Implementations
- Technical Comparison with Similar Compounds
- Inquiry & Custom Solutions
1. Product Overview & Specifications
Chemical Name: 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
CAS Number: [Insert CAS]
Molecular Formula: C8H6N2O2
Molecular Weight: 162.15 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Storage: 2-8°C in airtight containers
Key Parameters Comparison
| Parameter | 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Pyridine-3-carbonitrile Derivatives | Generic Nitrile Compounds |
|---|---|---|---|
| Solubility | Moderate in DMSO, DMF | Variable | Low |
| Reactivity | High (methoxy group) | Moderate | Low |
| Pharma Relevance | FDA-approval intermediates | Limited | N/A |
2. Applications & Use Cases
2.1 Pharmaceutical Intermediate
Critical in synthesizing kinase inhibitors (e.g., anti-cancer agents) due to its electron-withdrawing cyano group.
2.2 Agrochemical Precursor
Used in herbicides/pesticides targeting plant-specific enzymes.
2.3 Material Science
Building block for conductive polymers in OLEDs.
3. Case Studies: Real-World Implementations
Case 1: Oncology Drug Development
Client: Top 10 Global Pharma Company
Challenge: Improve yield of a Bruton’s tyrosine kinase (BTK) inhibitor intermediate.
Solution: Optimized coupling reactions using 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile under inert conditions.
Result: 22% yield increase, reduced side products.
Case 2: Crop Protection Formulation
Client: EU Agrochemical Manufacturer
Challenge: Develop non-neonicotinoid insecticide.
Solution: Synthesized novel nitrile-based compound via selective methoxylation.
Result: 95% pest mortality in field trials, EPA approval.
4. Technical Comparison with Similar Compounds
| Property | 4-Methoxy Derivative | 4-Chloro Derivative | Parent Pyridinecarbonitrile |
|---|---|---|---|
| Electrophilicity (Hammett σ) | +0.78 | +0.92 | +0.66 |
| Thermal Stability (°C) | ≤180 | ≤160 | ≤200 |
| API Compatibility | High | Moderate (toxicity) | Low |
5. Inquiry & Custom Solutions
Leverage our GMP-certified synthesis expertise for:
- Bulk quantities (100kg+/batch)
- Isotope-labeled versions (13C, 15N)
- Custom functionalization (e.g., halogenation)
Contact:
Email: info@vivalr.com
Tel: (86) 15866781826
Request COA, MSDS, or formulation support within 24hrs.
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