4-Chloropyridine-2-carboxamide: Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
| Parameter | 4-Chloropyridine-2-carboxamide | N-Methyl Derivative* |
|---|---|---|
| CAS Number | 99586-65-9 | 220000-87-3 |
| Molecular Formula | C6H5ClN2O | C7H7ClN2O |
| Molecular Weight | 156.57 g/mol | 170.60 g/mol |
| Appearance | Off-white crystalline powder | Tan solid |
| Melting Point | Not specified | 41-43°C |
| Density | Not specified | 1.3 g/cm³ |
| Purity | ≥98% | ≥99% |
*N-Methyl-4-chloropyridine-2-carboxamide shown for comparative purposes
2. Key Applications
Pharmaceutical Intermediates
Critical building block in synthesis of kinase inhibitors including:
- Anticancer agents (e.g., sorafenib analogs)
- Tyrosine kinase inhibitors
- MAPK pathway modulators
Agrochemical Development
- Herbicide precursors
- Fungicide intermediates
Material Science
- Coordination complexes for catalysis
- Ligand synthesis for metal-organic frameworks
3. Usage Guidelines
Handling Requirements
- Storage: 2-8°C in sealed container
- Stability: ≥24 months when properly stored
- Incompatibilities: Strong oxidizers, acids
Reaction Optimization
| Application | Recommended Solvent | Temperature Range |
|---|---|---|
| Amide Coupling | DCM/THF (1:1) | 0-25°C |
| Nucleophilic Substitution | DMF | 60-80°C |
4. Case Studies
Case 1: Antineoplastic Agent Synthesis
Used as key intermediate in multi-step synthesis of novel VEGFR-2 inhibitor achieving 92% yield at kilogram scale.
Case 2: Catalytic System Development
Implemented as ligand in copper-catalyzed C-N coupling reactions with 15% efficiency improvement over traditional systems.
5. Client Success Stories
Pharmaceutical Manufacturer A
Reduced production costs by 18% through optimized synthesis protocols using our GMP-grade material.
Research Institute B
Accelerated drug discovery timeline by 6 months using our custom synthetic derivatives.
6. Request Quotation
For pricing, technical specifications, or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826


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