2-Bromo-5-(trifluoromethyl)pyridine: Technical Guide & Procurement Insights
Table of Contents
- Product Specifications & Comparative Analysis
- Applications in Pharmaceutical & Agrochemical Industries
- Handling & Safety Guidelines
- Case Studies: Synthetic Route Optimization
- Client Success Stories
- Request Custom Synthesis or Bulk Quotation
1. Product Specifications & Comparative Analysis
| Parameter | 2-Bromo-5-(trifluoromethyl)pyridine | 2-Chloro-5-(trifluoromethyl)pyridine | 5-(Trifluoromethyl)pyridine-2-iodide |
|---|---|---|---|
| CAS Number | 76041-72-4 | 79456-26-1 | 89402-27-5 |
| Molecular Formula | C6H3BrF3N | C6H3ClF3N | C6H3F3IN |
| Purity (HPLC) | >98% | >97% | >95% |
| Melting Point | 34-36°C | 29-31°C | 41-43°C |
| Reactivity in Suzuki Coupling | High (Pd-catalyzed) | Moderate | Low thermal stability |
2. Key Industrial Applications
Pharmaceutical Intermediates
Widely used in synthesis of:
- JAK3 kinase inhibitors for autoimmune therapies
- BTK inhibitors in oncology research
- FLT3-targeting compounds for leukemia treatment
Agrochemical Development
- Key precursor for fluorinated neonicotinoid alternatives
- Building block for systemic fungicides
3. Safety & Storage Protocols
| Parameter | Requirement |
|---|---|
| Storage Temperature | 2-8°C in sealed argon-filled containers |
| Shelf Life | 24 months when stored properly |
| Incompatible Materials | Strong oxidizers, metallic sodium |
4. Application Case Studies
Case 1: Scale-up of Anticancer Compound
Challenge: A biotech firm required 50kg of high-purity intermediate under tight deadlines.
Solution: Our team optimized Buchwald-Hartwig amination conditions using 2-Bromo-5-TFMP as key substrate, achieving 82% yield at 200L scale.
Case 2: Novel Fungicide Development
Challenge: An agrochemical company needed selective fluorination at position 5.
Result: Enabled synthesis of broad-spectrum fungicide with LC50 of 0.8ppm against Botrytis cinerea.
5. Verified Client Testimonials
ABC Pharmaceuticals (Germany)
“Used 12kg batch in our BTK inhibitor program – consistent ≥99% purity via UPLC analysis. Enabled first-pass API crystallization success.”
AgroChem Solutions Ltd (USA)
“Critical input for our next-gen fungicide line. Technical support team helped resolve regioselectivity issues in SNAr reactions.”
6. Request Customized Service
Our capabilities:
- Batch sizes from 100g to 500kg
- Custom halogenation patterns
- Isotope-labeled versions (D, 13C, 15N)
Contact our technical team:
Email: info@vivalr.com
Tel: +86 15866781826
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