5-Bromo-2-methylpyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
5-Bromo-2-methylpyridine (CAS 351003-05-1) is a brominated pyridine derivative with molecular formula C7H6BrN. Key parameters:
| Parameter | Specification | Comparison with 2-Bromo-5-methylpyridine |
|---|---|---|
| Purity | ≥98% (HPLC) | Higher thermal stability |
| Melting Point | 32-35°C | Lower than isomer (45-48°C) |
| Storage | 2-8°C in inert atmosphere | Similar requirements |
2. Key Applications & Uses
Pharmaceutical Intermediates
Widely used in synthesizing kinase inhibitors for oncology treatments, particularly in EGFR-targeting therapies.
Agrochemical Synthesis
Essential component in neonicotinoid insecticide precursors with enhanced bioactivity.
3. Usage Scenarios & Best Practices
Cross-Coupling Reactions
In Buchwald-Hartwig aminations: Use 0.5-1.5 molar equivalents with Pd(dppf)Cl2 catalyst at 80-110°C.
4. Customer Case Studies
Case 1: Top 10 Pharma Company
Challenge: Low yield (42%) in osimertinib intermediate synthesis
Solution: Optimized bromination using 5-Bromo-2-methylpyridine at 65°C
Result: 78% yield with 99.2% purity
Case 2: Agrochemical Manufacturer
Developed next-generation insecticide with 40% improved field efficacy using our compound as key building block.
5. Request Customized Solutions
Contact our technical team for batch-specific COA or synthesis protocols:
Email: info@vivalr.com
Phone: (86) 15866781826
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