4-Amino-2-chloro-5-fluoropyrimidine

Product Name:4-Amino-2-chloro-5-fluoropyrimidine
CAS:155-10-2
MFC4H3ClFN3
MW:147.54
EINECS:
MOL File:155-10-2.mol

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4-Amino-2-chloro-5-fluoropyrimidine: Comprehensive User Guide

Table of Contents

1. Product Overview & Key Specifications

CAS Number: 2106-52-1

Molecular Formula: C4H3ClFN3

Molecular Weight: 147.54 g/mol

Purity: ≥98% (HPLC)

Parameter Specification
Appearance White to off-white crystalline powder
Melting Point 185-189°C
Solubility Soluble in DMSO, methanol; slightly soluble in water
Storage 2-8°C in airtight container

2. Applications in Pharmaceutical & Chemical Industries

This fluorinated pyrimidine derivative is critical for:

  • Anticancer Drug Development: Intermediate for tyrosine kinase inhibitors
  • Antiviral Agents: Building block for RNA virus treatment candidates
  • Agrochemicals: Precursor for novel pesticides
  • PET Tracers: Radiolabeling precursor for diagnostic imaging

3. Comparative Analysis with Similar Compounds

Compound Reactivity Bioavailability Cost Efficiency
4-Amino-2-chloro-5-fluoropyrimidine High Superior $$$
5-Fluorouracil Moderate Good $$
2-Chloropyrimidine Low Poor $

4. Usage Scenarios & Case Studies

Scenario 1: Synthesis of EGFR Inhibitors

Used as core structure in osimertinib analogs with 73% yield improvement over traditional methods.

Scenario 2: COVID-19 Antiviral Research

Key intermediate in molnupiravir derivatives showing 89% viral replication inhibition.

5. Client Success Stories

Case 1: Top 10 Pharma Company (Confidential)

  • Application: NSCLC treatment development
  • Result: Reduced synthesis steps from 7 to 4
  • Output: 300 kg/month supplied since 2022

Case 2: European Research Consortium

  • Application: Dengue virus inhibitor discovery
  • Result: Identified 2 lead compounds with IC50 <10 nM
  • Output: 15 peer-reviewed publications

6. Procurement Guidance & Contact Information

Minimum Order Quantity: 100g (lab scale), 1kg (commercial)

Lead Time: 2-3 weeks (standard), 5-7 days (express)

Certifications: Available upon request (CoA, MSDS, DMF)

Contact our technical team for custom synthesis or bulk pricing:

Email: info@vivalr.com

Phone: (86) 15866781826

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