4-Amino-2-chloro-5-fluoropyrimidine: Comprehensive User Guide
Table of Contents
- 1. Product Overview & Key Specifications
- 2. Applications in Pharmaceutical & Chemical Industries
- 3. Comparative Analysis with Similar Compounds
- 4. Usage Scenarios & Case Studies
- 5. Client Success Stories
- 6. Procurement Guidance & Contact Information
1. Product Overview & Key Specifications
CAS Number: 2106-52-1
Molecular Formula: C4H3ClFN3
Molecular Weight: 147.54 g/mol
Purity: ≥98% (HPLC)
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Melting Point | 185-189°C |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
| Storage | 2-8°C in airtight container |
2. Applications in Pharmaceutical & Chemical Industries
This fluorinated pyrimidine derivative is critical for:
- Anticancer Drug Development: Intermediate for tyrosine kinase inhibitors
- Antiviral Agents: Building block for RNA virus treatment candidates
- Agrochemicals: Precursor for novel pesticides
- PET Tracers: Radiolabeling precursor for diagnostic imaging
3. Comparative Analysis with Similar Compounds
| Compound | Reactivity | Bioavailability | Cost Efficiency |
|---|---|---|---|
| 4-Amino-2-chloro-5-fluoropyrimidine | High | Superior | $$$ |
| 5-Fluorouracil | Moderate | Good | $$ |
| 2-Chloropyrimidine | Low | Poor | $ |
4. Usage Scenarios & Case Studies
Scenario 1: Synthesis of EGFR Inhibitors
Used as core structure in osimertinib analogs with 73% yield improvement over traditional methods.
Scenario 2: COVID-19 Antiviral Research
Key intermediate in molnupiravir derivatives showing 89% viral replication inhibition.
5. Client Success Stories
Case 1: Top 10 Pharma Company (Confidential)
- Application: NSCLC treatment development
- Result: Reduced synthesis steps from 7 to 4
- Output: 300 kg/month supplied since 2022
Case 2: European Research Consortium
- Application: Dengue virus inhibitor discovery
- Result: Identified 2 lead compounds with IC50 <10 nM
- Output: 15 peer-reviewed publications
6. Procurement Guidance & Contact Information
Minimum Order Quantity: 100g (lab scale), 1kg (commercial)
Lead Time: 2-3 weeks (standard), 5-7 days (express)
Certifications: Available upon request (CoA, MSDS, DMF)
Contact our technical team for custom synthesis or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826


评论
目前还没有评论。