1. Product Overview & Specifications

Basic Information

Chemical Name: 3-Hydroxypyridine

CAS No.: 109-00-2

Molecular Formula: C₅H₅NO

Molecular Weight: 95.10 g/mol

Appearance: Pale yellow to brown crystalline powder

Key Physical Properties

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2. Key Applications

Pharmaceutical Intermediates

Widely used in synthesizing antidepressants, antiviral agents, and other bioactive molecules. Reacts with iron(III) chloride to form red complexes, enabling analytical applications.

Organic Synthesis

Essential for constructing pyridine derivatives, heterocyclic compounds, and coordination complexes. Its hydroxyl group enables functionalization via alkylation or acylation.

Research & Development

Employed in metabolite studies (e.g., depression-related research in Sprague-Dawley rats) and material science for corrosion inhibitors.

3. Usage Scenarios

Lab-Scale Synthesis

Protocol: Dissolve 5g in 50mL ethanol under nitrogen. React with 2eq acetic anhydride at 60°C for 4hrs. Yield: 85%.

Industrial Production

Process: Pyridine sulfonation → Alkali fusion (220–230°C, 4hrs) → Neutralization (pH 8–9) → Crystallization. Typical yield: 64%.

4. Case Studies

Case 1: Leyan Reagent

Application: Supplied 98% purity material for ADC linker development in a Shanghai-based biopharma company. Enabled 99.5% final product purity.

Case 2: Hubei Shixing Chemical

Project: Custom synthesis of 3-hydroxypyridine derivatives for corrosion inhibitor research. Achieved 10% efficiency improvement vs. commercial benchmarks.

Case 3: Hubei Hongxin Ruifine

Usage: Provided GMP-grade batches for antidepressant API production. Met USP/EP specifications with ≤0.1% impurities.

5. Contact for Technical & Commercial Inquiries

Email: info@vivalr.com

Phone: (86) 15866781826

Request a quote: Specify purity (98–99.9%), quantity (mg to kg), and application details.