1. Product Overview & Specifications

2,4-Dibromopyrimidine (CAS 19194-96-0) is a brominated heterocyclic compound with molecular formula C₄H₂Br₂N₂ and molecular weight 261.88 g/mol. This white crystalline solid is widely used as a building block in pharmaceutical and agrochemical synthesis.

2. Key Applications

This versatile intermediate enables:

• Pharmaceutical synthesis (antiviral/anticancer agents)
• Agrochemical production (herbicide intermediates)
• OLED material development
• Cross-coupling reactions (Suzuki, Buchwald-Hartwig)

3. Usage Scenarios

3.1 Suzuki-Miyaura Coupling

Used as coupling partner with arylboronic acids under Pd catalysis (1 mol% Pd(PPh₃)₄, K₂CO₃, DMF/H₂O, 80°C) to produce biarylpyrimidines.

3.2 Nucleophilic Substitution

Reacts with amines (1:2 molar ratio, DIPEA, DCM, RT) to create diamino-pyrimidine derivatives for kinase inhibitors.

4. Client Case Studies

Case 1: Top 10 Pharma Company (EU)

Application: Synthesis of Bruton’s tyrosine kinase (BTK) inhibitor intermediate
Result: 92% yield in Buchwald-Hartwig amination
Scale: 150 kg batch production

Case 2: Agrochemical Leader (USA)

Application: Herbicide intermediate for rice crops
Process: Two-step bromination sequence
Output: 40% cost reduction vs traditional routes

5. Technical Inquiry

Our technical team provides:

• Custom synthesis protocols
• Regulatory support (REACH, TSCA)
• Kilogram-to-ton scale production

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826