6-Chloro-2-methyl-3-nitropyridine

Product Name:6-Chloro-2-methyl-3-nitropyridine
CAS:22280-60-0
MFC6H5ClN2O2
MW:172.57
EINECS:
MOL File:22280-60-0.mol

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6-Chloro-2-methyl-3-nitropyridine: Comprehensive User Guide

1. Product Overview & Specifications

Basic Information

  • Chemical Name: 6-Chloro-2-methyl-3-nitropyridine
  • CAS Number: 22280-60-0
  • Molecular Formula: C6H5ClN2O2
  • Molecular Weight: 172.57 g/mol
  • Appearance: Pale yellow crystalline solid
  • Purity: ≥98% (GC)

Physical-Chemical Properties

Parameter Value
Melting Point 53–57°C
Boiling Point 255.9°C at 760 mmHg
Density 1.406 g/cm³
Flash Point 108.5°C
Refractive Index 1.575

Supplier Comparison

Brand Purity Packaging Price (USD)
Acmec 98% 25g, 100g $35.90 (25g), $127.50 (100g)
Tanmo Quality 98% 1g $30.00

2. Key Applications

6-Chloro-2-methyl-3-nitropyridine serves as a critical intermediate in:

  • Pharmaceutical Synthesis: Production of antiviral agents and kinase inhibitors.
  • Agrochemicals: Development of herbicides and pesticides.
  • Material Science: Precursor for functionalized polymers and coordination complexes.

3. Usage Guidelines

Recommended Workflow

  1. Storage: Keep in a cool, dry place (≤25°C) away from light and moisture.
  2. Handling: Use under fume hood with nitrile gloves and safety goggles.
  3. Reaction Conditions: Optimize at 60–80°C in inert solvents (e.g., DMF, THF).

4. Safety & Handling

Hazard Classification (GHS)

  • H315: Causes skin irritation
  • H319: Causes serious eye irritation
  • H335: May cause respiratory irritation

Preventive Measures

  • Use PPE: Lab coat, gloves, and face shield.
  • Avoid inhalation; ensure proper ventilation.

5. Client Case Studies

Case Study 1: Antiviral Drug Development

Client: A European pharmaceutical company utilized the compound to synthesize a novel RNA polymerase inhibitor, achieving 92% yield in key coupling reactions.

Case Study 2: Herbicide Formulation

Client: An agrochemical manufacturer integrated the product into a next-generation herbicide, enhancing weed-control efficacy by 40%.

6. Contact for Inquiries

For pricing, bulk orders, or technical support:

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