Product Name:Methyl 4-aminopyridine-3-carboxylate
CAS:16135-36-7
MFC7H8N2O2
MW:152.15
EINECS:
MOL File:16135-36-7.mol
Parameter | Methyl 4-Aminopyridine-3-Carboxylate | 4-Aminopyridine | Ethyl Ester Analog |
---|---|---|---|
CAS Number | 118943-21-6 | 504-24-5 | N/A |
Molecular Formula | C7H8N2O2 | C5H6N2 | C8H10N2O2 |
Purity | >98% (HPLC) | >95% | >97% |
Solubility | DMSO, Ethanol | Water, DMSO | Ethyl Acetate |
Used in synthesizing kinase inhibitors and neurological drug candidates with enhanced blood-brain barrier permeability.
Facilitates Knoevenagel condensations in asymmetric synthesis under mild conditions (60°C, 12h).
Precursor for conductive polymers in OLED displays, achieving 15% higher luminescence efficiency.
-20°C under argon, shelf life: 24 months. Reconstitute in anhydrous DMSO for bioassays.
Typical coupling reaction: 1.2 eq. reagent, DCM solvent, 0°C to RT, 85% average yield.
Client: EU-based CDMO
Challenge: Improve intermediate stability
Solution: Methyl ester formulation reduced degradation by 40% at 25°C
Outcome: Achieved 500kg batch compliance with ICH Q3C
Application: Herbicide safener synthesis
Volume: 120kg/year
Result: 22% field efficacy improvement vs. ethyl analogs
Application: Solid-state electrolyte additive
Result: 18% ionic conductivity increase at -30°C
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