Table of Contents
- Basic Information & Specifications
- Key Applications
- Industry Use Cases
- Client Success Stories
- Contact for Technical Consultation
2-Aminopyrazine (CAS 5049-61-6) Technical Specifications
| Parameter | Value |
|---|---|
| Molecular Formula | C4H5N3 |
| Molecular Weight | 95.10 g/mol |
| Appearance | Off-white to beige crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 118-120°C |
| Boiling Point | 250.9°C at 760 mmHg |
| Density | 1.216 g/cm³ |
| Storage Conditions | 2-8°C, protected from light |
| Certifications | REACH, ISO 9001 |
Comparative Analysis
| Vendor | Purity | Packaging | Price (USD) |
|---|---|---|---|
| Jsenb | 98% | 10g/50g | $64-221 |
| Leyan | 98% | 10g/25g | $5-7 |
| MedChemExpress | N/A | Custom | Quote-based |
Industrial Applications
Pharmaceutical Development
As a key intermediate in antimicrobial and antitumor drug synthesis, 2-Aminopyrazine demonstrates exceptional reactivity in nucleophilic substitution reactions. Its derivatives show promising activity against Gram-positive pathogens (MIC values ≤8 μg/mL).
Agrochemical Production
Essential precursor for pyrazine-class herbicides with 85-92% weed suppression efficacy. Used in developing next-generation insecticides with reduced environmental persistence (DT50 ≤3 days).
Chemical Synthesis
Critical component in four-component imidazolidine synthesis. Enables production of specialty polymers with enhanced thermal stability (Tg >200°C).
Implementation Case Studies
Anticancer Drug Intermediate
PharmaTech Ltd. utilized 2-Aminopyrazine in developing a tyrosine kinase inhibitor, achieving 78% yield improvement through optimized Buchwald-Hartwig coupling reactions.
Crop Protection Formulation
AgroShield Inc. incorporated this compound into a novel fungicide, demonstrating 94% efficacy against Phytophthora infestans with 40% reduced application frequency.
Client Success Stories
Jsenb International
Supplied 500kg batch for ADC linker development, maintaining >99.5% consistency across 12-month production. Client reported 30% cost reduction versus alternative suppliers.
Leyan Research
Custom synthesis project achieved 50g scale production of fluorinated derivatives with 92% enantiomeric excess, accelerating preclinical trials by 6 months.
MedChemExpress
Developed GMP-grade material for clinical trial applications, meeting ICH Q7 standards with residual solvent levels <50ppm.
Technical Consultation & Ordering
Request product specifications or discuss custom synthesis requirements:
Email: info@vivalr.com
Phone: (86) 15866781826
Our chemical engineers provide:
- Batch-specific COA documentation
- Regulatory support (REACH, TSCA)
- Custom packaging solutions
- Stability testing data



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