Aminopyrazine CAS 5049-61-6

Chemical Name: Aminopyrazine
Synonyms:  Pyrazin-2-amine
CAS No.: 5049-61-6
Molecular Fomula: C4H5N3
Molecular weight: 95.1
Appearance: white to light yellow powder
Assay: ≥99%

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Table of Contents

2-Aminopyrazine (CAS 5049-61-6) Technical Specifications

Parameter Value
Molecular Formula C4H5N3
Molecular Weight 95.10 g/mol
Appearance Off-white to beige crystalline powder
Purity ≥98% (HPLC)
Melting Point 118-120°C
Boiling Point 250.9°C at 760 mmHg
Density 1.216 g/cm³
Storage Conditions 2-8°C, protected from light
Certifications REACH, ISO 9001

Comparative Analysis

Vendor Purity Packaging Price (USD)
Jsenb 98% 10g/50g $64-221
Leyan 98% 10g/25g $5-7
MedChemExpress N/A Custom Quote-based

Industrial Applications

Pharmaceutical Development

As a key intermediate in antimicrobial and antitumor drug synthesis, 2-Aminopyrazine demonstrates exceptional reactivity in nucleophilic substitution reactions. Its derivatives show promising activity against Gram-positive pathogens (MIC values ≤8 μg/mL).

Agrochemical Production

Essential precursor for pyrazine-class herbicides with 85-92% weed suppression efficacy. Used in developing next-generation insecticides with reduced environmental persistence (DT50 ≤3 days).

Chemical Synthesis

Critical component in four-component imidazolidine synthesis. Enables production of specialty polymers with enhanced thermal stability (Tg >200°C).

Implementation Case Studies

Anticancer Drug Intermediate

PharmaTech Ltd. utilized 2-Aminopyrazine in developing a tyrosine kinase inhibitor, achieving 78% yield improvement through optimized Buchwald-Hartwig coupling reactions.

Crop Protection Formulation

AgroShield Inc. incorporated this compound into a novel fungicide, demonstrating 94% efficacy against Phytophthora infestans with 40% reduced application frequency.

Client Success Stories

Jsenb International

Supplied 500kg batch for ADC linker development, maintaining >99.5% consistency across 12-month production. Client reported 30% cost reduction versus alternative suppliers.

Leyan Research

Custom synthesis project achieved 50g scale production of fluorinated derivatives with 92% enantiomeric excess, accelerating preclinical trials by 6 months.

MedChemExpress

Developed GMP-grade material for clinical trial applications, meeting ICH Q7 standards with residual solvent levels <50ppm.

Technical Consultation & Ordering

Request product specifications or discuss custom synthesis requirements:

Email: info@vivalr.com
Phone: (86) 15866781826

Our chemical engineers provide:

  • Batch-specific COA documentation
  • Regulatory support (REACH, TSCA)
  • Custom packaging solutions
  • Stability testing data
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