2-Fluoro-4-iodopyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Fluoro-4-iodopyridine (CAS 112109-21-4) is a halogenated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key parameters include:
| Parameter | Value |
|---|---|
| Molecular Formula | C5H3FIN |
| Molecular Weight | 239.99 g/mol |
| Purity | ≥98% |
| Appearance | White to off-white crystalline powder |
Comparative Advantages:
- Higher reactivity than non-fluorinated pyridines
- Improved stability vs. chloro/bromo analogs
2. Key Applications
This compound serves as a versatile building block in:
- Pharmaceuticals: Kinase inhibitor development
- Agrochemicals: Herbicide intermediates
- Material Science: Liquid crystal precursors
Its unique meta-iodo/para-fluoro substitution pattern enables selective cross-coupling reactions.
3. Usage Guidelines
Recommended Protocols:
- Store at 2-8°C under inert atmosphere
- Use palladium catalysts for Suzuki couplings
- Optimize reaction temps between 80-110°C
Safety: Handle with nitrile gloves in fume hoods. Avoid strong oxidizers.
4. Case Studies
Case 1: Synthesis of EGFR Inhibitor
| Step | Condition | Yield |
|---|---|---|
| Borylation | Pd(dppf)Cl₂, 90°C | 82% |
| Amination | CuI, L-Proline | 76% |
5. Client Success Stories
PharmaTech Solutions: Achieved 40% cost reduction in API synthesis using our compound for selective fluorination.
AgroGuard Innovations: Developed novel fungicide with 95% efficacy against wheat rust.
UniMaterials Co.: Created OLED materials with 15% improved luminescence efficiency.
6. Contact for Inquiries
Request custom synthesis or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826
Same-day response guaranteed for technical queries.
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