2,6-Dichloro-1-fluoropyridinium Triflate: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2,6-Dichloro-1-fluoropyridinium triflate (CAS 220141-71-7) is a high-performance fluorination reagent widely used in organic synthesis. Key parameters:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥98% | 95-97% | 97% |
| Solubility | DCM, THF, MeCN | Limited in THF | DCM only |
| Storage | 2-8°C (dry) | Room temp | -20°C |
2. Key Applications & Use Cases
2.1 Fluorination Reactions
Enables efficient nucleophilic fluorination in:
- Pharmaceutical intermediates (e.g., PET radiotracers)
- Agrochemical synthesis
- Electronic material precursors
2.2 Reaction Optimization
Typical reaction conditions:
Substrate (1 eq) + 2,6-DCFPT (1.2 eq)
Solvent: DCM/MeCN (2:1)
Temperature: 0°C → RT
Yield: 82-95%
3. Industrial Case Studies
Case 1: Anticancer Drug Intermediate
Client: Top 10 Pharma Company (USA)
- Challenge: Low yield (48%) in fluoropyrimidine synthesis
- Solution: Replaced XtalFluor-E with 2,6-DCFPT
- Result: 89% yield, 99.5% HPLC purity
Case 2: OLED Material Production
Client: Advanced Materials Manufacturer (Japan)
- Challenge: Side reactions in fluorinated emitter synthesis
- Solution: Optimized stoichiometry (1:1.05 reagent ratio)
- Result: 94% conversion, reduced purification steps
4. Technical Support & Inquiry
Our chemical engineers provide:
- Custom synthesis protocols
- Bulk order optimization (100g-100kg scale)
- Regulatory documentation support
Contact our specialists:
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