Parameter | 4-Pyridineacetic Acid Hydrochloride | Common Analogues |
---|---|---|
CAS Number | 6622-91-9 | Varies (e.g., 62302-28-7 for 4-Pyridinemethanol HCl) |
Molecular Formula | C7H7NO2·HCl | C6H8ClNO (Pyridinemethanol HCl) |
Molecular Weight | 173.60 g/mol | 145.59 g/mol |
Melting Point | 141°C (decomposition) | ~200°C (varies by derivative) |
SMILES | OC(=O)Cc1ccncc1.Cl | N/A |
Hazard Class | Xi (Irritant) | Similar irritant properties |
Widely used in synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and neurological agents. Its pyridine moiety enables selective binding to biological targets.
Functions as a precursor for herbicides and fungicides due to its stability under harsh reaction conditions. Example: Synthesis of pyridine-based plant growth regulators.
Employed in metal-organic frameworks (MOFs) and coordination polymers, leveraging its carboxylate group for molecular assembly.
Solvent | Solubility (g/100mL) |
---|---|
Water | 32.7 (20°C) |
Ethanol | 18.9 |
DMSO | 41.2 |
Challenge: Low yield in EGFR inhibitor synthesis
Solution: Implemented 4-Pyridineacetic Acid HCl as coupling agent
Result: 37% yield improvement with 99.2% purity
Challenge: Photodegradation of active components
Solution: Added 0.5% w/w as stabilizer
Result: Shelf life extended from 6 to 18 months
Exposure Type | First Aid |
---|---|
Skin Contact | Flush with water ≥15 minutes |
Eye Contact | Irrigate with saline solution |
Inhalation | Administer oxygen if breathing impaired |
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