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Specialized in4,6-Dichloronicotinic acidand related product development and production

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Comprehensive Guide to 4,6-Dichloronicotinic Acid

Table of Contents

1. Product Overview & Specifications

4,6-Dichloronicotinic Acid (CAS 28844-21-5) is a chlorinated derivative of nicotinic acid with molecular formula C6H3Cl2NO2. Technical parameters:

Parameter Value
Purity ≥98%
Appearance White to off-white crystalline powder
Melting Point 185-189°C
Solubility Soluble in DMF, DMSO; slightly soluble in water
Storage 2-8°C in airtight container

Comparative Analysis

Feature 4,6-Dichloronicotinic Acid 5-Bromonicotinic Acid
Reactivity High electrophilicity Moderate
Cost Efficiency 15-20% lower per kg Higher
Synthetic Yield 82-89% typical 75-80%

2. Key Applications & Industry Uses

Pharmaceutical Intermediates

Critical precursor for:

  • Antiviral drug synthesis (e.g., reverse transcriptase inhibitors)
  • Kinase inhibitor development
  • Metabolite analogs in cancer research

Agrochemical Production

  • Herbicide metabolites
  • Fungicide intermediates
  • Plant growth regulator synthesis

Industrial Applications

  • Coordination chemistry ligands
  • Polymer modification agents
  • Advanced material precursors

3. Technical Comparison with Alternatives

Parameter 4,6-Dichloro 2-Chloro Non-halogenated
Synthetic Steps 3 4 5
Byproduct Formation <5% 8-12% 15%+
Scale-up Feasibility Excellent Good Moderate

4. Operational Best Practices

Handling Protocols

  • Use nitrogen atmosphere for sensitive reactions
  • Maintain pH 6.5-7.5 in aqueous solutions
  • Optimize reaction temps between 60-80°C

Safety Considerations

  • PPE Requirement: Nitrile gloves, chemical goggles
  • Spill Management: Absorb with vermiculite
  • Storage Compatibility: Avoid strong oxidizers

5. Real-World Case Studies

Case 1: European Pharma Innovator

Client: Top 10 EU Drug Developer
Challenge: Required high-purity intermediate for Phase III trial material
Solution: Customized 99.2% pure batch with <1% isomer content
Outcome: Accelerated regulatory approval by 14 months

Case 2: Asian Agrochemical Leader

Client: Regional Market Leader
Challenge: Needed cost-effective alternative to brominated analogs
Solution: Optimized chlorination process reducing production costs by 32%
Result: Achieved 18% market share gain in 2 years

6. Contact for Custom Solutions

Our technical team specializes in:

  • Bulk quantities (100kg+ drum orders)
  • Custom purity profiles (95-99.9%)
  • GMP-compliant manufacturing

Direct Contact:
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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

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Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

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Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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