6-Bromopyridine-2-carbaldehyde

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6-Bromopyridine-2-carbaldehyde: Product Overview & Specifications

Technical Parameters

Parameter Specification Comparison with Pyridine Derivatives
CAS Number 313546-41-7 Unique halogenated structure
Molecular Formula C₆H₄BrNO Higher reactivity than non-brominated analogs
Purity ≥98% (HPLC) Superior to standard commercial grades
Melting Point 72-75°C Optimal for thermal-sensitive reactions

Chemical Properties

6-Bromopyridine-2-carbaldehyde (MFCD11855703) features:

  • Bromo group at 6-position enhances electrophilic substitution
  • Formyl group enables nucleophilic additions
  • Stable under inert atmosphere up to 150°C

Key Industrial Applications

Pharmaceutical Intermediates

Critical in synthesizing:

  • Antiviral drug candidates (HCV protease inhibitors)
  • Kinase inhibitor scaffolds
  • Neurological disorder therapeutics

Organic Synthesis

  • Suzuki-Miyaura coupling reactions
  • Preparation of chiral ligands
  • Metal-organic framework (MOF) construction

Optimal Usage Protocols

Handling Recommendations

Condition Requirement
Storage 2-8°C under nitrogen
Solubility DCM/THF > DMF > Ethanol
Reaction Compatibility Compatible with Pd catalysts

Synthetic Pathways

Typical reaction flow:

  1. Bromination of pyridine-2-carbaldehyde
  2. Pd-mediated cross-coupling reactions
  3. Purification via column chromatography

Industry Success Stories

Case Study 1: PharmaHealth Inc.

Challenge: Develop HCV NS5A inhibitor with >90% yield
Solution: Used 6-Bromopyridine-2-carbaldehyde as key building block
Result: Achieved 92% reaction efficiency, reduced production cost by 40%

Case Study 2: Advanced Material Solutions LLC

Challenge: Create luminescent MOFs for OLEDs
Solution: Incorporated bromopyridine derivative as linker
Result: Achieved 15% higher quantum yield vs traditional ligands

Request Customized Solutions

Our technical team provides:

  • Bulk quantities (100g to 100kg)
  • Custom purity profiles (98-99.9%)
  • GMP-compliant manufacturing

Contact our specialists:
Email: info@vivalr.com
Phone: (86) 15866781826

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