3-Bromo-6-chloro-2-methylpyridine: Comprehensive User Guide
Table of Contents
Product Overview & Key Parameters
CAS No.: 132606-40-7
Molecular Formula: C6H5BrClN
Molecular Weight: 206.47 g/mol
Appearance: Off-white crystalline solid
Purity: ≥97% (GC)
Physical Properties
| Property | Value |
|---|---|
| Melting Point | 47°C |
| Boiling Point | 220.6°C at 760 mmHg |
| Density | 1.624 g/cm³ |
| Flash Point | 87.2°C |
Safety Information
| GHS Classification | Hazard Statements |
|---|---|
| GHS07 | H315 (Skin irritation) H319 (Eye irritation) H335 (Respiratory irritation) |
Applications & Industrial Uses
Pharmaceutical Intermediates
Widely used in synthesizing kinase inhibitors and anticancer agents due to its stable pyridine backbone and halogen substituents.
Agrochemical Production
Key precursor for herbicides and fungicides requiring selective halogen substitution patterns.
Material Science
Building block for metal-organic frameworks (MOFs) and specialty polymers.
Performance Comparison with Similar Compounds
| Compound | CAS | Melting Point | Reactivity | Typical Use |
|---|---|---|---|---|
| 3-Bromo-6-chloro-2-methylpyridine | 132606-40-7 | 47°C | Moderate | Pharma intermediates |
| 2-Bromo-6-chloro-3-methylpyridine | 867377-03-5 | N/A | High | Organic synthesis |
| 3-Bromo-6-chloro-2-fluoropyridine | 885952-18-1 | N/A | Low | Electrophilic substitution |
Usage Guidelines & Best Practices
Storage Conditions
Store in sealed containers at 2-8°C under inert atmosphere. Avoid prolonged exposure to humidity.
Handling Precautions
Use PPE including nitrile gloves and safety goggles. Conduct reactions in fume hoods due to dust formation risk.
Industry Case Studies
Case 1: Anticancer Drug Development
A European pharmaceutical company utilized this compound as a key intermediate in third-generation EGFR inhibitor synthesis, achieving 92% yield in Buchwald-Hartwig amination steps.
Case 2: Crop Protection Formulation
Leading agrochemical manufacturer incorporated the compound into novel strobilurin fungicides, demonstrating 40% improved field efficacy compared to previous formulations.
Inquiry & Technical Support
For bulk pricing, SDS, or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Quality Assurance
All batches include GC-MS purity certificates and meet ISO 9001:2015 standards. Custom packaging available from 1g to 100kg scale.
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