2-Bromo-4-pyridinecarboxaldehyde: Technical Guide & Application Insights
Table of Contents
- Product Specifications & Comparative Analysis
- Functional Applications in Pharmaceutical & Chemical Synthesis
- Operational Guidelines & Safety Protocols
- Industry Case Studies
- Client Success Stories
- Request Customized Quotation
1. Key Specifications & Comparative Analysis
| Parameter | 2-Bromo-4-pyridinecarboxaldehyde | 2-Chloro-4-pyridinecarboxaldehyde | 4-Pyridinecarboxaldehyde |
|---|---|---|---|
| CAS Number | 117522-21-3 | 102003-73-6 | 6224-79-5 |
| Molecular Formula | C6H4BrNO | C6H4ClNO | C6H5NO |
| Molecular Weight | 202.01 g/mol | 157.56 g/mol | 121.12 g/mol |
| Reactivity (Suzuki Coupling) | High bromine mobility | Moderate reactivity | Not applicable |
| Storage Conditions | 2-8°C under inert gas | Ambient with desiccant | Refrigerated |
2. Core Applications in Target Industries
Pharmaceutical Intermediates
Critical building block for kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents. The aldehyde group enables Schiff base formation for drug candidate optimization.
Material Science Applications
- Coordination polymer synthesis
- Ligand precursor for catalytic systems
- Photoactive compound development
3. Handling & Storage Protocols
| Safety Parameter | Requirement |
|---|---|
| GHS Classification | H302-H315-H319-H335 |
| PPE Requirements | Chemical goggles, Nitrile gloves, Type II respirator |
| Spill Management | Absorb with vermiculite, neutralize with 5% acetic acid |
4. Industrial Implementation Scenarios
Case A: API Intermediate Synthesis
Challenge: Develop scalable route to Bruton’s tyrosine kinase (BTK) inhibitor intermediate
Solution: Cross-coupling with boronic ester using Pd(PPh3)4 catalyst
Yield Improvement: 68% → 82% after process optimization
5. Client Implementation Results
PharmaCorp Ltd. (Switzerland)
Project: HER2-positive breast cancer drug candidate
Application: Key fragment for antibody-drug conjugate (ADC) linker
Batch Consistency: 99.7% purity across 12 production batches
Advanced Material Institute (USA)
Research: Conductive metal-organic frameworks (MOFs)
Result: Achieved 12.3% increase in charge transfer efficiency
6. Request Technical Consultation
Optimize your synthesis workflow with our GMP-grade bromopyridine derivatives:
Email: info@vivalr.com
Tel: (86) 15866781826
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