3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Basic Parameters
| Parameter | Value |
|---|---|
| CAS Number | 89402-26-0 |
| Molecular Formula | C6H3ClF3NO |
| Molecular Weight | 213.55 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Storage | 2-8°C in airtight container |
Competitive Advantages vs. Analogues
| Feature | This Product | Similar Compounds |
|---|---|---|
| Trifluoromethyl Group | Yes | Limited availability |
| Chloro-Hydroxy Synergy | Ortho-positioned | Meta/para positions common |
| Solubility | DMSO >100 mg/mL | Typically <50 mg/mL |
2. Key Applications & Use Cases
Pharmaceutical Intermediates
Critical building block for:
- Kinase inhibitor development (JAK/STAT pathway targets)
- Antiviral drug candidates (HCV/HIV protease inhibition)
- PET tracer synthesis (18F-labeling precursor)
Agrochemical Formulations
- Herbicide metabolites (soil persistence studies)
- Fungicidal compound optimization
3. Industry Case Studies
Case 1: Antiviral Drug Development
Client: Top 10 Global Pharma Company (EU-based)
Application: Synthesis of NS5A replication complex inhibitors
Result: Achieved 92% yield in Buchwald-Hartwig amination step
Case 2: Herbicide Metabolite Research
Client: Agrochemical Leader (USA)
Application: Environmental fate studies of trifluoromethyl pyridines
Result: Identified stable transformation products for regulatory filings
4. Safety & Handling Guidelines
| Aspect | Requirement |
|---|---|
| Personal Protection | Nitrile gloves, chemical goggles |
| Ventilation | Fume hood required for bulk handling |
| Spill Management | Absorb with vermiculite, dispose as halogen waste |
5. Contact for Custom Solutions
Request bulk pricing or technical support:
Email: info@vivalr.com
Tel: (86) 15866781826
Ask about:
- Custom purity requirements (up to 99.9%)
- Isotope-labeled variants (13C/15N)
- Kilogram-scale synthesis
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