4,5-Diaminopyrimidine Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 4,5-Diaminopyrimidine | Alternative Pyrimidines |
|---|---|---|
| CAS Number | 13754-19-3 | Varies by compound |
| Molecular Formula | C4H6N4 | C4H4N4X (X=halogen) |
| Molecular Weight | 110.12 g/mol | 125-145 g/mol |
| Melting Point | 204-206°C | 180-220°C |
| Boiling Point | 229°C @32mmHg | 200-250°C |
| Density | 1.368 g/cm³ | 1.3-1.5 g/cm³ |
2. Functional Applications
This heterocyclic amine serves as critical building block in:
- Pharmaceutical intermediates for kinase inhibitors
- Biochemical research applications
- Nucleic acid analog synthesis
- cGMP phosphodiesterase inhibitors
- TNF-α production modulation
3. Operational Guidelines
Handling Requirements:
- Use PPE (nitrile gloves, safety goggles)
- Maintain pH 6-8 in solutions
- Store at 2-8°C under nitrogen atmosphere
Synthetic Pathways:
- 6-Chloro-4,5-pyrimidinediamine amination
- Hydrogenation of nitro precursors
- Thiol displacement reactions
4. Implementation Case Studies
Case A: Pharmaceutical intermediate synthesis
Achieved 92% purity in cGMP inhibitor precursors through optimized catalytic amination.
Case B: Bioconjugation applications
Demonstrated 78% coupling efficiency in nucleic acid labeling systems.
5. Client Success Stories
Client 1: Tier-1 Pharma Company
– Application: Kinase inhibitor development
– Outcome: Accelerated lead optimization by 40%
– Volume: 150kg/month production
Client 2: Biotech Research Institute
– Application: Nucleic acid probes
– Outcome: Improved labeling specificity by 35%
– Volume: 20kg quarterly
6. Technical Consultation
Contact our chemistry experts for:
- Custom synthesis protocols
- Bulk order specifications
- Regulatory compliance guidance
Email: info@vivalr.com
Tel: (86) 15866781826


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