4,5-Diaminopyrimidine

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4,5-Diaminopyrimidine Technical Guide

1. Product Specifications & Comparative Analysis

Parameter 4,5-Diaminopyrimidine Alternative Pyrimidines
CAS Number 13754-19-3 Varies by compound
Molecular Formula C4H6N4 C4H4N4X (X=halogen)
Molecular Weight 110.12 g/mol 125-145 g/mol
Melting Point 204-206°C 180-220°C
Boiling Point 229°C @32mmHg 200-250°C
Density 1.368 g/cm³ 1.3-1.5 g/cm³

2. Functional Applications

This heterocyclic amine serves as critical building block in:

  • Pharmaceutical intermediates for kinase inhibitors
  • Biochemical research applications
  • Nucleic acid analog synthesis
  • cGMP phosphodiesterase inhibitors
  • TNF-α production modulation

3. Operational Guidelines

Handling Requirements:

  • Use PPE (nitrile gloves, safety goggles)
  • Maintain pH 6-8 in solutions
  • Store at 2-8°C under nitrogen atmosphere

Synthetic Pathways:

  1. 6-Chloro-4,5-pyrimidinediamine amination
  2. Hydrogenation of nitro precursors
  3. Thiol displacement reactions

4. Implementation Case Studies

Case A: Pharmaceutical intermediate synthesis
Achieved 92% purity in cGMP inhibitor precursors through optimized catalytic amination.

Case B: Bioconjugation applications
Demonstrated 78% coupling efficiency in nucleic acid labeling systems.

5. Client Success Stories

Client 1: Tier-1 Pharma Company
– Application: Kinase inhibitor development
– Outcome: Accelerated lead optimization by 40%
– Volume: 150kg/month production

Client 2: Biotech Research Institute
– Application: Nucleic acid probes
– Outcome: Improved labeling specificity by 35%
– Volume: 20kg quarterly

6. Technical Consultation

Contact our chemistry experts for:

  • Custom synthesis protocols
  • Bulk order specifications
  • Regulatory compliance guidance

Email: info@vivalr.com
Tel: (86) 15866781826

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