1. Product Overview & Specifications

CAS Number: 123148-78-7

Molecular Formula: C₆H₃ClIN₃

Appearance: White to off-white crystalline powder

Specification Comparison

2. Key Applications

This heterocyclic compound serves as a critical intermediate in:

• Antiviral drug development (particularly nucleoside analogs)
• Kinase inhibitor synthesis
• Preparation of Janus kinase (JAK) inhibitor intermediates
• Pharmaceutical impurity profiling (e.g., Tofacitinib-related substances)
• Protecting group strategies in organic synthesis (e.g., tert-butyl ester derivatives)

3. Usage Scenarios

Case 1: Nucleoside Analog Synthesis

Used in the preparation of 7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl) derivatives under inert atmosphere (argon), employing standard coupling conditions (DCE, TMSOTf, 0°C to rt).

Case 2: Kinase Inhibitor Development

Serves as a core structure for selective JAK3 inhibitors through sequential Suzuki-Miyaura cross-coupling reactions with boronic esters.

4. Customer Case Studies

Shanghai Yuanye Bio-Technology

Provided 25g batches for a multinational pharma company’s antiviral screening program, achieving >99% HPLC purity after column chromatography.

Macklin Biochemical

Supplied 500mg quantities to academic researchers studying kinase inhibition mechanisms, with successful crystallization for X-ray diffraction analysis.

AmyJet Scientific

Supported a Canadian biotech firm’s scale-up project, delivering 50g under cGMP-like conditions for preclinical trials.

5. Contact for Quotation

Request custom synthesis or bulk pricing:

Email: info@vivalr.com
Tel: (86) 15866781826

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