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2-Fluoro-3-iodopyridine: Comprehensive User Guide for Researchers and Industry Professionals
Table of Contents
1. Product Overview & Specifications
2-Fluoro-3-iodopyridine (CAS 374624-28-9) is a halogenated pyridine derivative with molecular formula C5H3F1I1N1 and molecular weight 239.00 g/mol. This heterocyclic compound features:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥98% (HPLC) | ≥95% | ≥97% |
| Appearance | White crystalline powder | Off-white powder | Yellowish crystals |
| Storage | 2-8°C in dark glass | Ambient | 4-10°C |
| Solubility | DMSO, DMF, THF | Limited in DMF | DMSO only |
2. Key Applications & Use Cases
Pharmaceutical Intermediates
Widely used in Suzuki-Miyaura cross-coupling reactions for:
- Anticancer drug development (kinase inhibitors)
- Antiviral compound synthesis
- PET radiotracer production
Material Science Applications
- Liquid crystal precursor synthesis
- OLED material development
- Coordination chemistry ligands
3. Performance Comparison
| Feature | 2-Fluoro-3-iodopyridine | 3-Bromo-2-fluoropyridine | 2-Chloro-5-iodopyridine |
|---|---|---|---|
| Reactivity in Cross-Coupling | Excellent (I > Br) | Good | Moderate |
| Steric Effects | Low | Moderate | High |
| Thermal Stability | Up to 150°C | 120°C | 100°C |
4. Industry Case Studies
Case 1: Oncology Drug Development
Client: Top 10 Pharma Company (EU-based)
Application: Synthesis of FGFR inhibitor candidates
Result: 40% yield improvement vs. brominated analogs
Case 2: Electronic Materials Production
Client: Advanced Materials Manufacturer (Japan)
Application: Hole-transport layer synthesis
Result: Achieved 15% higher conductivity
Case 3: Academic Research
Client: Ivy League University (USA)
Application: Radiolabeling for tumor imaging
Result: Successful in vivo tracking at 90% efficiency
5. Technical Support & Inquiry
Our team provides:
- Custom synthesis services
- Bulk order optimization
- Technical documentation (MSDS, CoA)
Contact our specialists for project-specific solutions:
Email: info@vivalr.com
Phone: (86) 15866781826
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