| Parameter | 5-Amino-2-chloropyrimidine | Similar Compounds |
|---|---|---|
| CAS Number | 17228-65-4 | N/A |
| Molecular Formula | C4H4ClN3 | Varies by derivative |
| Purity Grade | Pharmaceutical (≥99%) | Industrial (95-98%) |
| Storage Conditions | 2-8°C in inert atmosphere | Room temperature |
Pharmaceutical Intermediates: Critical building block for HIV protease inhibitors and kinase-targeted oncology drugs. Enables selective functionalization at the 4-position through nucleophilic aromatic substitution.
Agrochemical Synthesis: Key precursor for neonicotinoid insecticides with improved hydrolytic stability compared to 2-amino derivatives.
Material Science: Used in coordination chemistry to create luminescent metal-organic frameworks (MOFs) with nitrogen-rich coordination sites.
Challenge: Required scale-up from lab (50g) to pilot plant (20kg) while maintaining ≤0.5% dimeric impurities.
Solution: Optimized Buchwald-Hartwig coupling conditions using BrettPhos precatalyst (0.5 mol%) at 80°C in dioxane/water biphasic system.
Outcome: Achieved 92% yield with 99.7% HPLC purity, reducing API production costs by 18%.
Challenge: Develop photostable insecticide formulation resistant to UV degradation.
Solution: Synthesized chloropyrimidine-neonicotinoid hybrid through radical trifluoromethylation at 4-position.
Outcome: Field trials showed 40% longer residual activity compared to imidacloprid benchmarks.
Critical Quality Parameters:
- Residual solvent levels (DMF < 500ppm)
- Heavy metal content (Pd < 10ppm)
- Particle size distribution (D90 < 50µm for consistent reactions)
Supply Chain Best Practices:
1. Request batch-specific 13C NMR spectra for ring substitution verification
2. Validate thermal stability through DSC analysis (decomposition onset >150°C)
3. Conduct accelerated stability studies (40°C/75% RH for 6 months)
For COA samples, bulk pricing (100kg+ quantities), or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Our chemical engineering team provides:
- Regulatory support (REACH, FDA DMF filings)
- Process optimization consulting
- Custom halogenation services
This is William, CEO of fousi chemical Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
