2-Chloro-3-(trifluoromethyl)pyridine

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2-Chloro-3-(trifluoromethyl)pyridine: Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

Chemical Properties

Parameter Value Comparison with Similar Compounds
CAS Number 89402-43-7 Unique identifier vs. pyridine derivatives
Molecular Formula C6H3ClF3N Distinct from 2-chloro-5-(trifluoromethyl)pyridine
Purity >98% Higher than standard commercial grades
Storage 2-8°C under inert gas More stable than non-fluorinated analogs

Technical Advantages

  • Enhanced electrophilic reactivity for nucleophilic substitutions
  • Superior stability in catalytic cross-coupling reactions
  • Low LC50 value: 128 mg/L (96h, fish)

2. Key Applications & Use Cases

Pharmaceutical Intermediates

  • Synthesis of JAK2 kinase inhibitors
  • Building block for antiviral agents

Agrochemical Development

  • Key component in next-gen herbicides
  • Insecticide resistance management formulations

3. Industry-Specific Usage Scenarios

Lab-Scale Optimization

  • Typical reaction conditions: 80-110°C in DMF
  • Recommended catalyst: Pd(dppf)Cl2

Industrial Manufacturing

  • Batch process optimization data
  • Safety protocols for large-scale handling

4. Real Customer Case Studies

Case Study 1: European Pharma Company

  • Application: Oncology drug intermediate
  • Result: 22% yield improvement vs. previous synthesis route

Case Study 2: Asian Agrochemical Leader

  • Application: Herbicide resistance breaker
  • Result: Field efficacy increased by 40%

5. Procurement Guidance

Quality Verification

  • HPLC analysis specifications
  • Batch-to-batch consistency reports

Regulatory Compliance

  • REACH registration status
  • Customs documentation support

6. Contact for Custom Solutions

Request technical documents or discuss bulk pricing:

Request SDS or COA: Specify batch number and application requirements

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