4,6-Dihydroxypyrimidine Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Value |
|---|---|
| CAS Number | 1193-24-4 |
| Molecular Formula | C4H4N2O2 |
| Molecular Weight | 112.09 g/mol |
| Appearance | Pale yellow to orange crystalline powder |
| Melting Point | >300°C |
| Solubility | 2.5 g/L in water (20°C), soluble in alkaline solutions |
| Storage | Sealed container, dry/ventilated area, ≤25°C |
2. Applications & Industrial Uses
Key Applications:
- Pharmaceutical Intermediate: Synthesis of sulfonamide drugs (e.g., sulfamonomethoxine), vitamin B4, and antitumor agents.
- Chemical Synthesis: Building block for heterocyclic compounds in agrochemicals and specialty chemicals.
- Research & Development: Precursor for developing bioactive molecules in medicinal chemistry.
3. Synthesis & Production Methods
Primary Synthesis Route:
- Cyclocondensation of diethyl/dibutyl malonate with formamide under controlled temperature (120-150°C).
- Yield optimization via pH adjustment (pH 8-9) and catalyst selection (e.g., sodium methoxide).
Process Efficiency: >85% purity achieved through recrystallization in hot water.
4. Safety & Handling Protocols
| Hazard Code | Precautionary Measures |
|---|---|
| Xi (Irritant) |
|
Regulatory Compliance: WGK Germany 1 (Low water hazard), RTECS UW7523000.
5. Supplier Information
| Supplier | Specifications | Contact |
|---|---|---|
| Pande (Shanghai) International Trade | Pharma-grade, 25kg drums | Tel: +86 19901672645 Email: panda_sh@163.com |
| Shanghai Jichun Industrial | Lab-grade, 100g to 200kg | Tel: +86 13524933993 MOQ: 1kg |
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