Table of Contents
- Product Overview & Specifications
- Key Applications & Industry Uses
- Real-World Case Studies
- Procurement & Technical Selection Guide
- Contact for Custom Solutions
2-Bromo-3-Methoxypyridine: Product Overview & Specifications
Chemical Specifications
| Parameter | Specification | 2-Bromo-4-Methoxypyridine (Comparison) |
|---|---|---|
| CAS Number | 374598-44-4 | 16867-50-2 |
| Molecular Formula | C6H6BrNO | C6H6BrNO |
| Molecular Weight | 188.02 g/mol | 188.02 g/mol |
| Appearance | White to off-white crystalline powder | Pale yellow crystals |
| Purity (HPLC) | ≥99.5% | ≥98.0% |
| Melting Point | 72-75°C | 68-70°C |
Key Differentiators
Superior regioselectivity vs. brominated pyridine analogs, enhanced solubility in polar aprotic solvents (DMSO: 50 mg/mL), and optimized stability for Suzuki-Miyaura coupling reactions.
Key Applications & Industry Uses
Pharmaceutical Intermediates
Critical building block for:
- Kinase inhibitor development (JAK2/FLT3 targets)
- Antiviral prodrug synthesis
- Neuroactive compound functionalization
Material Science Applications
- Ligand precursor for transition metal catalysts
- Photoactive polymer modification
- Coordination chemistry templates
Real-World Implementation Case Studies
Case Study 1: Oncology Drug Development
Client: ABC Pharma (Top 20 Global Pharma)
Challenge: Required high-purity brominated pyridine derivative for lead optimization phase with strict residual metal limits (<10 ppm)
Solution: Supplied 2-Bromo-3-Methoxypyridine with:
- 99.8% HPLC purity
- Metal content: 5 ppm (Pd), 3 ppm (Ni)
- Custom particle size distribution (D90 <50µm)
Case Study 2: Advanced Material Synthesis
Client: XYZ Advanced Materials
Application: Development of luminescent coordination polymers
Technical Requirements:
- Batch-to-batch consistency in substituent positioning
- Stability under inert atmosphere processing
- Multi-kilogram quantities with COA traceability
Technical Procurement Guide
Quality Parameters for API-grade Material
| Parameter | Pharma Grade | Research Grade |
|---|---|---|
| Purity | ≥99.5% | ≥97.0% |
| Heavy Metals | <10 ppm | <50 ppm |
| Residual Solvents | Class 1: None Detected | Class 2 <5000 ppm |
Packaging Options
- Research Quantities: 1g-100g in amber glass vials
- Bulk Supply: 25kg fiber drums with desiccant
- Special Handling: Vacuum-sealed packages for hygroscopic batches
Contact for Technical Consultation
Request custom synthesis, bulk pricing, or regulatory documentation:
Email: info@vivalr.com
Tel: (86) 15866781826
Technical Support Hours: Mon-Fri 08:00-18:00 GMT+8
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