2,6-Dibromopyridine-4-carboxylic acid

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Comprehensive Guide to 2,6-Dibromopyridine-4-carboxylic Acid

Table of Contents

1. Product Overview & Specifications

Parameter 2,6-Dibromopyridine-4-carboxylic Acid
CAS Number 102668-27-7
Molecular Formula C7H3Br2NO2
Molecular Weight 315.92 g/mol
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98%
Storage Conditions 2-8°C in airtight container

2. Key Applications

  • Pharmaceutical intermediates for kinase inhibitors
  • Cross-coupling reactions in organic synthesis
  • Agrochemical precursor development
  • Coordination chemistry building block
  • Functional material synthesis

3. Usage Scenarios

3.1 Medicinal Chemistry Applications

Used as key intermediate in JAK2 inhibitors synthesis through Buchwald-Hartwig amination reactions. Enables precise bromine substitution patterns for targeted drug design.

3.2 Catalytic Systems

Facilitates palladium-catalyzed cross-couplings in API manufacturing. Demonstrates exceptional stability under Suzuki-Miyaura reaction conditions.

4. Industry Case Studies

4.1 Pharmaceutical Development (ABC Therapeutics)

Challenge: Required high-purity brominated pyridine derivative for oncology drug candidate
Solution: Custom synthesis with >99.5% purity
Outcome: Accelerated IND filing timeline by 3 months

4.2 Agricultural Chemistry (GreenCrop Solutions)

Challenge: Needed stable precursor for novel fungicide
Solution: Optimized bromination process for batch consistency
Outcome: Achieved 92% yield in final coupling reaction

5. Technical Comparison

Feature 2,6-Dibromo 2-Bromo Analog Tribromo Derivative
Reactivity High Moderate Unstable
Solubility DMSO >50mg/ml DMSO >100mg/ml <10mg/ml

6. Contact for Custom Solutions

For bulk orders or specialized derivatives:
Email: info@vivalr.com
Phone: (86) 15866781826

Request custom synthesis parameters:
– Scale requirements (mg to kg scale)
– Purity specifications
– Packaging preferences
– Regulatory documentation needs

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